Meissner's corpuscle
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| Meissner's corpuscle | |
|---|---|
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| "Sensory nerve endings for touch" labeled at upper right.) | |
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| Papilla of the hand, treated with acetic acid. Magnified 350 times. A. Side view of a papilla of the hand. a. Cortical layer. b. Tactile corpuscle. c. Small nerve of the papilla, with neurolemma. d. Its two nervous fibers running with spiral coils around the tactile corpuscle. e. Apparent termination of one of these fibers. B. A tactile papilla seen from above so as to show its transverse section. a. Cortical layer. b. Nerve fiber. c. Outer layer of the tactile body, with nuclei. d. Clear interior substance. | |
| Latin | corpusculum tactus |
| Gray's | subject #233 1061 |
| MeSH | Mechanoreceptors |
| Dorlands/Elsevier | c_56/12261393 |
Meissner's corpuscles (or tactile corpuscles) are a type of mechanoreceptor, responsible for sensitivity to light touch.
Location
They are distributed throughout the skin, but concentrated in areas especially sensitive to light touch, such as the fingertips, palms, soles, lips, tongue, face and the skin of the male and female genitals.
They are primarily located just beneath the epidermis within the dermal papillae.
Structure
Meissner's corpuscles are encapsulated unmyelinated nerve endings, which consist of flattened supportive cells arranged as horizontal lamellae surrounded by a connective tissue capsule. The corpuscle is between 30-140 μm in length and 40-60 μm in diameter
A single nerve fiber meanders between the lamellae and throughout the corpuscle.
Age Related Changes
The number of Meissner corpuscles per square millimeter of human skin on the fingertips drops fourfold between the ages of 12 and 50. The rate at which they are lost correlates well with the age-related loss in touch sensitivity for small probes (Thornbury and Mistretta, 1981).
Function
Any physical deformation in the corpuscle will cause an action potential in the nerve. Since they are rapidly adapting or phasic, the action potentials generated quickly decrease and eventually cease. (This is the reason one stops "feeling" one's clothes.)
If the stimulus is removed, the corpuscle regains its shape and while doing so (ie: while physically reforming) causes another volley of action potentials to be generated.
Because of their superficial location in the dermis, these corpuscles are particularly sensitive to touch and vibrations, but for the same reasons, they are limited in their detection because they can only signal that something is touching the skin.
Comparison with other receptors
Feelings of deep pressure (from a poke, for instance) are generated from Pacinian corpuscles (the only other type of phasic tactile mechanoreceptor), which are located deeper in the dermis, and some free nerve endings.
Also, Meissner's corpuscles do not detect pain; this is signalled exclusively by free nerve endings.
Eponym
Meissner's corpuscles were discovered by the anatomist Georg Meissner (1829-1905).
Additional images
 Diagrammatic sectional view of the skin. |
External links
- Donald L. Rubbelke D.A. Tissues of the Human Body: An Introduction. McGraw-Hill. 1999 Meissner's and Pacinian corpuscles
- Dawn A. Tamarkin, Ph.D. Anatomy and Physiology Unit 15 Vision and Somatic Senses: Touch and Pressure
- S Gilman. Joint position sense and vibration sense: anatomical organisation and assessment. Journal of Neurology Neurosurgery and Psychiatry 2002;73:473-477
- Histology at Boston University 08105loa - "Integument pigmented skin, Meissner's corpuscles "
- Anatomy Atlases - Microscopic Anatomy, plate 06.123 - "Meissner's Tactile Corpuscle"
- Histology at University of Southern California skn/c_13
- Histology at rutgers.eud
- tactile+corpuscle at eMedicine Dictionary
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
