Marginal zone
You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.
| Marginal zone | |
|---|---|
 | |
| Transverse section of a portion of the spleen. | |
| Gray's | subject #278 1284 |
The marginal zone is the region at the interface between the non-lymphoid red pulp and the lymphoid white-pulp of the spleen. (Some sources consider it to be the part of red pulp which borders on the white pulp, while other sources consider it to be neither red pulp nor white pulp.)
Composition and markers
It is composed of cells derived primarily from the myeloid compartment of bone marrow differentiation. At least three distinct cellular markers can be used to identify cells of the marginal zone, MOMA-1, ERTR-9 and MARCO.
Function
The major role of marginal zone is to trap particulate antigen from the circulation and present the antigen to the lymphocytes of the spleen.
Experiments have shown that inert latex beads as well as live bacteria such as Escherichia coli and Listeria monocytogenes are trapped by the marginal zone. However, only immunogenic substances, ie. bacteria, are trafficked to the T and B cell zones of the white-pulp and are efficiently presented to elicit an immune response.
Lymphocytes
Marginal zone lymphocytes are a type of B cell ("MZ B cell") created there, capable of binding IgM-antigen complexes. They are notable for their ability to serve several different roles in the immune system.
Pathology
It is associated with three different kinds of lymphoma:
- Splenic marginal zone lymphoma
- Extranodal marginal zone B cell lymphoma (MALT lymphoma, or "mucosa-associated lymphoid tissue")
- Nodal marginal zone B cell lymphoma (NMZL)
See also
External links
- Annual Review of Immunology
- BioMedCentral
- Marginal zone lymphomas
- JEM
- Kraal G. "Cells in the marginal zone of the spleen.". Int Rev Cytol 132: 31-74. PMID 1555921.
- Kumararatne D, MacLennan I (1981). "Cells of the marginal zone of the spleen are lymphocytes derived from recirculating precursors.". Eur J Immunol 11 (11): 865-9. PMID 6976895.
- Marginal+zone at eMedicine Dictionary
Immune system: Lymphatic system (Lymph, Lymphocytes) | |
|---|---|
| Primary | Bone marrow – Thymus (Hassall's corpuscles) |
| Secondary: Spleen (process blood) | Hilum – Trabeculae
Red pulp (Cords of Billroth, Marginal zone) White pulp (Periarteriolar lymphoid sheaths, Germinal center) Trabecular arteries – Trabecular veins |
| Secondary: Lymph nodes (process extracellular fluid) | Afferent lymph vessels - Cortical sinuses - Medullary sinuses - Efferent lymph vessels
T cells: High endothelial venules B cells: Primary follicle/Germinal center - Mantle zone - Marginal zone Lymph node capsule - Subcapsular sinus - Cortex - Paracortex - Medulla (Medullary cord) - Hilus Lymph node trabeculae |
| Secondary: MALT (process mucosa) | GALT – Peyer's patches – Germinal center |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
