Mallory-Weiss syndrome risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamed Diab, MD [2]


Overview

The most potent risk factors in the development of Mallory-Weiss syndrome are Alcohol use and Hiatal hernia. The less potent risk factor in the development of Mallory-Weiss syndrome is age.

Common Risk Factors

  • Alcohol use: 40% to 80% of patients with Mallory-Weiss syndrome has a history of heavy alcohol use which lead to vomiting.[1][2][3][4][5]
  • Hiatal hernia: It is still unclear if it is a risk factor or not. It is reported in 40% to 80% of patients with Mallory-Weiss syndrome but big case-control study found no big difference in prevalence of hiatal

hernia between patients with Mallory-Weiss syndrome and controls.[2][6]

Less Common Risk Factors

  • Age: Mallory-Weiss syndrome is suggested to be associated with increased age.[7] However, most tears happen in patients younger than 40, which suggests that age doesn't have a major role. Mallory-Weiss syndrome was also reported in infants. [8]

References

  1. Michel L, Serrano A, Malt RA (1980). "Mallory-Weiss syndrome. Evolution of diagnostic and therapeutic patterns over two decades". Ann. Surg. 192 (6): 716–21. PMC 1344969. PMID 7447523.
  2. 2.0 2.1 Dagradi AE, Broderick JT, Juler G, Wolinsky S, Stempien SJ (1966). "The Mallory-Weiss syndrome and lesion. A study of 30 cases". Am J Dig Dis. 11 (9): 710–21. PMID 5946360.
  3. Harris JM, DiPalma JA (1993). "Clinical significance of Mallory-Weiss tears". Am. J. Gastroenterol. 88 (12): 2056–8. PMID 8249973.
  4. Knauer CM (1976). "Mallory-Weiss syndrome. Characterization of 75 Mallory-weiss lacerations in 528 patients with upper gastrointestinal hemorrhage". Gastroenterology. 71 (1): 5–8. PMID 1084311.
  5. Sugawa C, Benishek D, Walt AJ (1983). "Mallory-Weiss syndrome. A study of 224 patients". Am. J. Surg. 145 (1): 30–3. PMID 6600377.
  6. Corral JE, Keihanian T, Kröner PT, Dauer R, Lukens FJ, Sussman DA (2017). "Mallory Weiss syndrome is not associated with hiatal hernia: a matched case-control study". Scand. J. Gastroenterol. 52 (4): 462–464. doi:10.1080/00365521.2016.1267793. PMID 28007004.
  7. Penston JG, Boyd EJ, Wormsley KG (1992). "Mallory-Weiss tears occurring during endoscopy: a report of seven cases". Endoscopy. 24 (4): 262–5. doi:10.1055/s-2007-1009122. PMID 1366134.
  8. Cannon RA, Lee G, Cox KL (1985). "Gastrointestinal hemorrhage due to Mallory-Weiss syndrome in an infant". J. Pediatr. Gastroenterol. Nutr. 4 (2): 323–4. PMID 3872935.


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