LFA-1
LFA-1 stands for Lymphocyte function-associated antigen-1.
LFA-1 is found on all T-cells and also on B-cells, macrophages and neutrophils and is involved in recruitment to the site of infection. It binds to ICAM-1 on antigen-presenting cells and functions as an adhesion molecule, it is the first to bind T-cells to antigen-presenting cells and initially binds weakly. A signal from the T-cell receptor changes the conformation and prolongs the cell contact, allowing the T-cell to proliferate.
LFA-1 is part of the family of leukocyte integrins which are recognised by their common β-chains (CD18). LFA-1 also has a distinct α-chain (CD11a).
See also
Further reading
- Janeway, Travers, Walport, Shlomchik, Immunobiology 6th ed. (2005) Garland Science:NY
External links
- MeSH LFA-1
- Davignon D, Martz E, Reynolds T, Kürzinger K, Springer TA (1981). "Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte-mediated killing". Proc. Natl. Acad. Sci. U.S.A. 78 (7): 4535–9. PMID 7027264.
Transmembrane receptors: immune receptors | |
|---|---|
| Cytokine receptor | Type I: interleukin (IL-2, IL-3) - CSF (Erythropoietin, GM-CSF, G-CSF) - Glycoprotein 130/Oncostatin M - Leukemia inhibitory factor - common subunits (Common gamma chain, CSF2RB) Type II: interleukin (IL22RA2) - interferon (IFNAR, IFNGR) |
| Pattern recognition/Toll-like | TLR 1 - TLR 2 - TLR 3 - TLR 4 - TLR 5 - TLR 6 - TLR 7 - TLR 8 - TLR 9 - TLR 10 |
| Fc receptor | ε (FcεRI, FcεRII) - γ (FcγRI, FcγRII, FcγRIII) - α/μ (FcαRI, Fcα/μR) - Neonatal |
| Lymphocyte homing receptor | CD44 - L-selectin - VLA-4 - LFA-1 |
| other | Antigen receptor (B-cell, T cell) - Complement - Formyl peptide - Immunophilins - Integrin - Killer-cell immunoglobulin-like - Scavenger |
Membrane proteins: cell adhesion molecules | |
|---|---|
| IgSF | N-CAM (Myelin protein zero) - ICAM (1, 4) - VCAM-1 - PE-CAM - L1-CAM |
| Cadherins | Desmoglein - T-cadherin |
| Selectins | E-selectin - L-selectin - P-selectin |
| Integrins | LFA-1 - Integrin alphaXbeta2 - Macrophage-1 antigen - VLA-4 - Glycoprotein IIb/IIIa (Note: integrins not always classified as CAMs) |
| Other | Carcinoembryonic antigen - CD22 - CD24 - CD44 - CD146 - CD164 |
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