KLK10
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| Kallikrein-related peptidase 10
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| Identifiers | ||||||||||||||
| Symbol(s) | KLK10; NES1; PRSSL1 | |||||||||||||
| External IDs | OMIM: 602673 MGI: 1916790 Homologene: 26428 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
| Image:PBB GE KLK10 209792 s at tn.png | ||||||||||||||
| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 5655 | 69540 | ||||||||||||
| Ensembl | ENSG00000129451 | ENSMUSG00000030693 | ||||||||||||
| Uniprot | O43240 | na | ||||||||||||
| Refseq | NM_001077500 (mRNA) NP_001070968 (protein) | NM_133712 (mRNA) NP_598473 (protein) | ||||||||||||
| Location | Chr 19: 56.21 - 56.22 Mb | Chr 7: 43.65 - 43.65 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Kallikrein-related peptidase 10, also known as KLK10, is a human gene.[1]
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.[1]
References
Further reading
- Diamandis EP, Yousef GM, Luo LY, et al. (2001). "The new human kallikrein gene family: implications in carcinogenesis.". Trends Endocrinol. Metab. 11 (2): 54-60. PMID 10675891.
- Zhang Y, Bhat I, Zeng M, et al. (2006). "Human kallikrein 10, a predictive marker for breast cancer.". Biol. Chem. 387 (6): 715-21. doi:10.1515/BC.2006.090. PMID 16800732.
- Liu XL, Wazer DE, Watanabe K, Band V (1996). "Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression.". Cancer Res. 56 (14): 3371-9. PMID 8764136.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
- Polikoff D, Kuo WL, Cochran JF, et al. (1998). "Assignment of protease, serine-like 1 (PRSSL1) to human chromosome 19q13 by in situ hybridization and radiation hybrid mapping.". Cytogenet. Cell Genet. 79 (1-2): 147-8. PMID 9533035.
- Luo L, Herbrick JA, Scherer SW, et al. (1998). "Structural characterization and mapping of the normal epithelial cell-specific 1 gene.". Biochem. Biophys. Res. Commun. 247 (3): 580-6. doi:10.1006/bbrc.1998.8793. PMID 9647736.
- Goyal J, Smith KM, Cowan JM, et al. (1998). "The role for NES1 serine protease as a novel tumor suppressor.". Cancer Res. 58 (21): 4782-6. PMID 9809976.
- Harvey TJ, Hooper JD, Myers SA, et al. (2001). "Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4.". J. Biol. Chem. 275 (48): 37397-406. doi:10.1074/jbc.M004525200. PMID 10969073.
- Gan L, Lee I, Smith R, et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.". Gene 257 (1): 119-30. PMID 11054574.
- Dhar S, Bhargava R, Yunes M, et al. (2002). "Analysis of normal epithelial cell specific-1 (NES1)/kallikrein 10 mRNA expression by in situ hybridization, a novel marker for breast cancer.". Clin. Cancer Res. 7 (11): 3393-8. PMID 11705853.
- Bharaj BB, Luo LY, Jung K, et al. (2002). "Identification of single nucleotide polymorphisms in the human kallikrein 10 (KLK10) gene and their association with prostate, breast, testicular, and ovarian cancers.". Prostate 51 (1): 35-41. PMID 11920956.
- Luo LY, Diamandis EP, Look MP, et al. (2002). "Higher expression of human kallikrein 10 in breast cancer tissue predicts tamoxifen resistance.". Br. J. Cancer 86 (11): 1790-6. doi:10.1038/sj.bjc.6600323. PMID 12087468.
- Petraki CD, Karavana VN, Luo LY, Diamandis EP (2002). "Human kallikrein 10 expression in normal tissues by immunohistochemistry.". J. Histochem. Cytochem. 50 (9): 1247-61. PMID 12185203.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
- Petraki CD, Gregorakis AK, Papanastasiou PA, et al. (2004). "Immunohistochemical localization of human kallikreins 6, 10 and 13 in benign and malignant prostatic tissues.". Prostate Cancer Prostatic Dis. 6 (3): 223-7. doi:10.1038/sj.pcan.4500674. PMID 12970725.
- Sauter ER, Lininger J, Magklara A, et al. (2004). "Association of kallikrein expression in nipple aspirate fluid with breast cancer risk.". Int. J. Cancer 108 (4): 588-91. doi:10.1002/ijc.11607. PMID 14696124.
- Diamandis EP, Scorilas A, Kishi T, et al. (2004). "Altered kallikrein 7 and 10 concentrations in cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementia.". Clin. Biochem. 37 (3): 230-7. doi:10.1016/j.clinbiochem.2003.11.012. PMID 14972646.
- Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529-35. doi:10.1038/nature02399. PMID 15057824.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
