Intraglomerular mesangial cell
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Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle.
There are three primary functions of intraglomerular mesangial cells: filtration, structural support, and phagocytosis.
Filtration and structure
Glomerular capillaries consist of endothelial cells with large fenestrations, and are therefore very permeable ("leaky") for most solutes in blood plasma.
They provide structural support for and regulate blood flow of the glomerular capillaries by their contractile activity.
They are also major contributors to the extracellular matrix which contains fibronectin, type IV collagen, perlecan, and laminin.
Phagocytosis
Mesangial cells also phagocytose glomerular basal lamina components and immunoglobulins.
See also
External links
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
