Inositol triphosphate receptor
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| inositol 1,4,5-triphosphate receptor, type 1
| |
| Identifiers | |
| Symbol | ITPR1 |
| Entrez | 3708 |
| HUGO | 6180 |
| OMIM | 147265 |
| RefSeq | NM_002222 |
| UniProt | Q14643 |
| Other data | |
| Locus | Chr. 3 p26.1 |
| inositol 1,4,5-triphosphate receptor, type 2
| |
| Identifiers | |
| Symbol | ITPR2 |
| Entrez | 3709 |
| HUGO | 6181 |
| OMIM | 600144 |
| RefSeq | NM_002223 |
| UniProt | Q14571 |
| Other data | |
| Locus | Chr. 12 p11.23 |
| inositol 1,4,5-triphosphate receptor, type 3
| |
| Identifiers | |
| Symbol | ITPR3 |
| Entrez | 3710 |
| HUGO | 6182 |
| OMIM | 147267 |
| RefSeq | NM_002224 |
| UniProt | Q14573 |
| Other data | |
| Locus | Chr. 6 p21.31 |
Inositol triphosphate receptor (IP3R) is a membrane glycoprotein complex acting as Ca2+ channel activated by inositol triphosphate (IP3).
Distribution
It has a broad tissue distribution but is especially abundant in the cerebellum. Most of the IP3R's are found in the cell integrated into the endoplasmic reticulum.
Structure
The IP3R complex is formed of four 313 kDa subunits. In amphibians, fish and mammals there are 3 paralogs and these can form homo- or hetero-oligomers. IP3R-1 is the most widely expressed of these three and is found in all tissue types and all developmental stages of life. It is additionally the means for further IP3 receptor diversity in that it has as many as four splice sites with as many as 9 different optional exons or exon variants. Combinations of these can be introduced into a given transcript in order to modulate its pharmacological activity.
See also
- inositol
- inositol phosphate
- myo-inositol (inositol monophosphate).
- inositol triphosphate
- inositol pentakisphosphate
- inositol hexaphosphate
External links
 | This protein-related article is a stub. You can help WikiDoc by expanding it. |
Cell signaling: lipid signaling |
|---|
| Phospholipase - PIP2 - DAG - IP3 - IP3 receptor |
Membrane transport protein: ion channels | |
|---|---|
| Ca2+: Calcium channel | Voltage-dependent calcium channel (L-type/Cav1.2, Cav2.1, N-type, P-type, Q-type, R-type, T-type) - Inositol triphosphate receptor - Ryanodine receptor - Cation channels of sperm - Two-pore channel |
| Na+: Sodium channel | Nav1.4 - Nav1.5 - Nav1.7- Nav1.9 - Epithelial sodium channel |
| K+: Potassium channel | Voltage-gated (Kv1.1, KvLQT1, KvLQT2, KvLQT3, HERG, Shaker gene, KCNE1) - Calcium-activated (BK channel, SK channel, SK3) - Inward-rectifier (ROMK, Kir2.1, KCNJ11) - Tandem pore domain |
| Cl-: Chloride channel | Cystic fibrosis transmembrane conductance regulator |
| Porin | Aquaporin (1, 2, 3, 4) - Voltage-dependent anion channel |
| Cations: TRP | TRPA - TRPC (TRPC6) - TRPM (TRPM6) - TRPML (Mucolipin-1) - TRPP - TRPV (TRPV1, TRPV6) |
| Other/general | Voltage-gated ion channel - Ligand-gated ion channel - Cyclic nucleotide-gated ion channel - Stretch-activated ion channel |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
