Immunoglobulin D

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Evidence Based Medicine
Cochrane Collaboration on Immunoglobulin D Bandolier on Immunoglobulin D TRIP on Immunoglobulin D
Clinical Trials
Ongoing Trials on Immunoglobulin D at Clinical Trials.gov Trial results on Immunoglobulin D Clinical Trials on Immunoglobulin D at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Immunoglobulin D NICE Guidance on Immunoglobulin D NHS PRODIGY Guidance FDA on Immunoglobulin D CDC on Immunoglobulin D
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Commentary
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Immunoglobulin D (IgD) is an antibody isotype that makes up about 1% of proteins in the plasma membranes of immature B-lymphocytes where it is usually coexpressed with another cell surface antibody called IgM. IgD is also produced in a secreted form that is found in very small amounts in blood serum. Secreted IgD is produced as a monomeric antibody with two heavy chains of the delta (δ) class, and two Ig light chains.

Function

IgD's function is currently unknown, as mice lacking IgD seem to retain normal immune responses (implying redundancy if not lack of function), and IgD ceases to be expressed in activated B-lymphocytes. It may function as a regulatory antigen receptor.

See also

• Antibody

External links

• MeSH Immunoglobulin+D

v • d • e Immune system / Immunology
Systems	Adaptive immune system vs. Innate immune system • Humoral immune system vs. Cellular immune system • Complement system (Anaphylatoxins) • Intrinsic immune system
Antibodies and antigens	Antibody (Monoclonal antibodies, Polyclonal antibodies, Autoantibody) • Allotype • Isotype • Idiotype • Antigen (Superantigen)
Immune cells	White blood cells (T cell, B cell, NK cell, Mast cell, Basophil, Eosinophil) • Phagocyte (Neutrophil, Macrophage, Dendritic cell) • Antigen-presenting cell • Reticuloendothelial system
Immunity vs. tolerance	Immunity • Autoimmunity • Allergy • Tolerance (Central) • Immunodeficiency
Immunogenetics	Somatic hypermutation • V(D)J recombination • Immunoglobulin class switching • MHC / HLA
Substances	Cytokines • Opsonin • Cytolysin
Other	Inflammation • Epitope (Hapten) • Cross-reactivity

v • d • e Immune system proteins
Antibodies	Light chain, Heavy chain, IgA, IgD, IgE, IgG, IgM
Other	MAC complex - Nanobodies - Perforin

v • d • e WikiDoc Research Resources for Immunoglobulin D (Click show to right to view)
Articles on Immunoglobulin D	Most recent articles on Immunoglobulin D • Most cited articles on Immunoglobulin D • Review articles on Immunoglobulin D • Articles on Immunoglobulin D in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Immunoglobulin D	Powerpoint slides on Immunoglobulin D • Images of Immunoglobulin D • Photos of Immunoglobulin D • Podcasts & MP3s on Immunoglobulin D • Videos on Immunoglobulin D
Evidence Based Medicine Regarding Immunoglobulin D	Cochrane Collaboration on Immunoglobulin D • Bandolier on Immunoglobulin D • TRIP on Immunoglobulin D
Cost Effectiveness of Immunoglobulin D	Cost Effectiveness of Immunoglobulin D
Clinical Trials Involving Immunoglobulin D	Ongoing Trials on Immunoglobulin D at Clinical Trials.gov • Trial results on Immunoglobulin D • Clinical Trials on Immunoglobulin D at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Immunoglobulin D	US National Guidelines Clearinghouse on Immunoglobulin D • NICE Guidance on Immunoglobulin D • NHS PRODIGY Guidance • FDA on Immunoglobulin D • CDC on Immunoglobulin D
Textbook Information on Immunoglobulin D	Books and Textbook Information on Immunoglobulin D
Pharmacology Resources on Immunoglobulin D	Dosing of Immunoglobulin D • Drug interactions with Immunoglobulin D • Side effects of Immunoglobulin D • Allergic reactions to Immunoglobulin D • Overdose information on Immunoglobulin D • Carcinogenicity information on Immunoglobulin D • Immunoglobulin D in pregnancy • Pharmacokinetics of Immunoglobulin D •
Genetics, Pharmacogenomics, and Proteinomics of Immunoglobulin D	Genetics of Immunoglobulin D • Pharmacogenomics of Immunoglobulin D • Proteomics of Immunoglobulin D
Newstories on Immunoglobulin D	Immunoglobulin D in the news • Be alerted to news on Immunoglobulin D • News trends on Immunoglobulin D
Commentary on Immunoglobulin D	Blogs on Immunoglobulin D
Patient Resources on Immunoglobulin D	Patient resources on Immunoglobulin D • Discussion groups on Immunoglobulin D • Patient Handouts on Immunoglobulin D • Directions to Hospitals Treating Immunoglobulin D • Risk calculators and risk factors for Immunoglobulin D
Healthcare Provider Resources on Immunoglobulin D	Symptoms of Immunoglobulin D • Causes & Risk Factors for Immunoglobulin D • Diagnostic studies for Immunoglobulin D • Treatment of Immunoglobulin D
Continuing Medical Education (CME) Programs on Immunoglobulin D	CME Programs on Immunoglobulin D
International Resources on Immunoglobulin D	Immunoglobulin D en Espanol • Immunoglobulin D en Francais
Business Resources on Immunoglobulin D	Immunoglobulin D in the Marketplace • Patents on Immunoglobulin D
Informatics Resources on Immunoglobulin D	List of terms related to Immunoglobulin D

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .