Hsc70
| heat shock 70kDa protein 8
| |
| Identifiers | |
| Symbol | HSPA8 |
| Alt. Symbols | HSPA10 |
| Entrez | 3312 |
| HUGO | 5241 |
| OMIM | 600816 |
| RefSeq | NM_153201 |
| UniProt | P11142 |
| Other data | |
| Locus | Chr. 11 q23.3-q25 |
Hsc70 is a heat shock protein. An ATPase that works with auxilin to remove clathrin coated vesicles.
In neurons, synaptojanin is also an important protein involved in vesicle uncoating. Hsc70 is also called Hsp73. The human gene name is HSPA8. It is in the DnaK heat shock protein family.
Unlike canonical heat shock proteins, Hsc70 is constitutively expressed and performs functions related to normal cellular processes. Hsc70 was placed in the heat shock protein family due to homology with other heat shock proteins.
Human Hsc70 has 85% identity with human Hsp70 (SDSC workbench, blosom26 default analysis).
The scientific community has long assumed that Hsp70 and Hsc70 have similar cellular roles, but this assumption proved erroneous.[1]
References
- ↑ Goldfarb S, Kashlan O, Watkins J, Suaud L, Yan W, Kleyman T, Rubenstein R (2006). "Differential effects of Hsc70 and Hsp70 on the intracellular trafficking and functional expression of epithelial sodium channels". Proc Natl Acad Sci U S A 103 (15): 5817-22. PMID 16585520.
External links
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Chaperones | |
|---|---|
| Heat shock proteins/Chaperonins | Hsp10/GroES - Hsp27 - Hsp47 - Hsp60/GroEL - Hsp70 (Hsc70) - Hsp90 |
| Other | Alpha crystallin - Clusterin |
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