euchromatic histone-lysine N-methyltransferase 1
|Locus||Chr. 9 |
Histone methyltransferases (HMT) are enzymes, histone-lysine N-methyltransferase and histone-arginine N-methyltransferase, which catalyze the transfer of one to three methyl groups from the cofactor S-Adenosyl methionine to lysine and arginine residues of histone proteins. These proteins often contain an SET (Su(var)3-9, Enhancer of Zeste, Trithorax) domain, however the recently discovered HMT Dot1 lacks the characteristic SET domain.
- Histone-Modifying Enzymes
- Histone acetyltransferase
- Histone deacetylase
- RNA polymerase control by chromatin structure
Methylated histones can either repress or activate transcription as different experimental findings suggest.
Transferase: one carbon transferases (EC 2.1)
|2.1.1 - Methyltransferases||5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase - Betaine-homocysteine methyltransferase - Catechol-O-methyl transferase - Histamine N-methyltransferase - Homocysteine methyltransferase - 5-Methyltetrahydrofolate-homocysteine methyltransferase - Phosphatidyl ethanolamine methyltransferase - Phenylethanolamine N-methyltransferase - DNMT3B - Histone methyltransferase - Thymidylate synthase - Tryptamine N-methyltransferase - DNA methyltransferase|
|2.1.2 - Hydroxy methyl-, Formyl- and Related Transferases||Serine hydroxymethyltransferase - Phosphoribosylglycinamide formyltransferase - Inosine monophosphate synthase - Glutamate formimidoyltransferase - Aminomethyltransferase|
|2.1.3 - Carboxy- and Carbamoyl transferases||Ornithine transcarbamylase|
|2.1.4 - Amidino transferases||Arginine:glycine amidinotransferase|
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