High endothelial venules
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
High endothelial venules, or HEVs, are a subtype of blood endothelium present within lymph nodes; used by various leukocytes to gain entry into the lymph node via the blood.[1]
The HEVs are made up of cuboidal endothelial cells, with various receptors to allow entry/rolling interactions between leukocytes and the endothelium.
High endothelial venules are found in lymph nodes and tonsils and Peyer's patches, but not in the thymus or spleen.[2]
References
Immune system: Lymphatic system (Lymph, Lymphocytes) | |
|---|---|
| Primary | Bone marrow – Thymus (Hassall's corpuscles) |
| Secondary: Spleen (process blood) | Hilum – Trabeculae
Red pulp (Cords of Billroth, Marginal zone) White pulp (Periarteriolar lymphoid sheaths, Germinal center) Trabecular arteries – Trabecular veins |
| Secondary: Lymph nodes (process extracellular fluid) | Afferent lymph vessels - Cortical sinuses - Medullary sinuses - Efferent lymph vessels
T cells: High endothelial venules B cells: Primary follicle/Germinal center - Mantle zone - Marginal zone Lymph node capsule - Subcapsular sinus - Cortex - Paracortex - Medulla (Medullary cord) - Hilus Lymph node trabeculae |
| Secondary: MALT (process mucosa) | GALT – Peyer's patches – Germinal center |
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