High endothelial venules

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High endothelial venules, or HEVs, are a subtype of blood endothelium present within lymph nodes; used by various leukocytes to gain entry into the lymph node via the blood.^[1]

The HEVs are made up of cuboidal endothelial cells, with various receptors to allow entry/rolling interactions between leukocytes and the endothelium.

High endothelial venules are found in lymph nodes and tonsils and Peyer's patches, but not in the thymus or spleen.^[1]

References

de:High endothelial venule

v • d • e Immune system: Lymphatic system (Lymph, Lymphocytes)
Primary	Bone marrow – Thymus (Hassall's corpuscles)
Secondary: Spleen (process blood)	Hilum – Trabeculae Red pulp (Cords of Billroth, Marginal zone) White pulp (Periarteriolar lymphoid sheaths, Germinal center) Trabecular arteries – Trabecular veins
Secondary: Lymph nodes (process extracellular fluid)	Afferent lymph vessels - Cortical sinuses - Medullary sinuses - Efferent lymph vessels T cells: High endothelial venules B cells: Primary follicle/Germinal center - Mantle zone - Marginal zone Lymph node capsule - Subcapsular sinus - Cortex - Paracortex - Medulla (Medullary cord) - Hilus Lymph node trabeculae
Secondary: MALT (process mucosa)	GALT – Peyer's patches – Germinal center

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Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .