Herbimycin

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Herbimycin
Image:Herbimycin.svg
IUPAC name	[(2R,3S,5S,6R,7S,8E,10R,11S,12E,14E)- 2,5,6,11-tetramethoxy-3,7,9,15-tetramethyl- 16,20,22-trioxo-17-azabicyclo[16.3.1] docosa-8,12,14,18,21-pentaen-10-yl] carbamate
Molecular formula	C30H42N2O9
Identifiers
CAS number	70563-58-5
PubChem	6436247
Properties
Molar mass	574.66 g/mol
Solubility	hygroscopic
Hazards
Main hazards	toxic
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

WikiDoc Resources for Herbimycin
Articles
Most recent articles on Herbimycin Most cited articles on Herbimycin Review articles on Herbimycin Articles on Herbimycin in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Herbimycin Images of Herbimycin Photos of Herbimycin Podcasts & MP3s on Herbimycin Videos on Herbimycin
Evidence Based Medicine
Cochrane Collaboration on Herbimycin Bandolier on Herbimycin TRIP on Herbimycin
Clinical Trials
Ongoing Trials on Herbimycin at Clinical Trials.gov Trial results on Herbimycin Clinical Trials on Herbimycin at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Herbimycin NICE Guidance on Herbimycin NHS PRODIGY Guidance FDA on Herbimycin CDC on Herbimycin
Books
Books on Herbimycin
News
Herbimycin in the news Be alerted to news on Herbimycin News trends on Herbimycin
Commentary
Blogs on Herbimycin
Definitions
Definitions of Herbimycin
Patient Resources / Community
Patient resources on Herbimycin Discussion groups on Herbimycin Patient Handouts on Herbimycin Directions to Hospitals Treating Herbimycin Risk calculators and risk factors for Herbimycin
Healthcare Provider Resources
Symptoms of Herbimycin Causes & Risk Factors for Herbimycin Diagnostic studies for Herbimycin Treatment of Herbimycin
Continuing Medical Education (CME)
CME Programs on Herbimycin
International
Herbimycin en Espanol Herbimycin en Francais
Businness
Herbimycin in the Marketplace Patents on Herbimycin
Experimental / Informatics
List of terms related to Herbimycin

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Herbimycin is a benzoquinone ansamycin antibiotic that binds to Hsp90 (Heat Shock Protein 90) and alters its function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis.

It was originally found by its herbicidal activity, and thus named.

Synonyms

• Antibiotic Tan 420F
• Herbimycin A

Biological activity

Herbimycin induces the degradation of proteins that are mutated in tumor cells such as v-Src, Bcr-Abl and p53 preferentially over their normal cellular counterparts. This effect is mediated via HSP90.

See also

• Geldanamycin

v • d • e WikiDoc Research Resources for Herbimycin (Click show to right to view)
Articles on Herbimycin	Most recent articles on Herbimycin • Most cited articles on Herbimycin • Review articles on Herbimycin • Articles on Herbimycin in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Herbimycin	Powerpoint slides on Herbimycin • Images of Herbimycin • Photos of Herbimycin • Podcasts & MP3s on Herbimycin • Videos on Herbimycin
Evidence Based Medicine Regarding Herbimycin	Cochrane Collaboration on Herbimycin • Bandolier on Herbimycin • TRIP on Herbimycin
Cost Effectiveness of Herbimycin	Cost Effectiveness of Herbimycin
Clinical Trials Involving Herbimycin	Ongoing Trials on Herbimycin at Clinical Trials.gov • Trial results on Herbimycin • Clinical Trials on Herbimycin at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Herbimycin	US National Guidelines Clearinghouse on Herbimycin • NICE Guidance on Herbimycin • NHS PRODIGY Guidance • FDA on Herbimycin • CDC on Herbimycin
Textbook Information on Herbimycin	Books and Textbook Information on Herbimycin
Pharmacology Resources on Herbimycin	Dosing of Herbimycin • Drug interactions with Herbimycin • Side effects of Herbimycin • Allergic reactions to Herbimycin • Overdose information on Herbimycin • Carcinogenicity information on Herbimycin • Herbimycin in pregnancy • Pharmacokinetics of Herbimycin •
Genetics, Pharmacogenomics, and Proteinomics of Herbimycin	Genetics of Herbimycin • Pharmacogenomics of Herbimycin • Proteomics of Herbimycin
Newstories on Herbimycin	Herbimycin in the news • Be alerted to news on Herbimycin • News trends on Herbimycin
Commentary on Herbimycin	Blogs on Herbimycin
Patient Resources on Herbimycin	Patient resources on Herbimycin • Discussion groups on Herbimycin • Patient Handouts on Herbimycin • Directions to Hospitals Treating Herbimycin • Risk calculators and risk factors for Herbimycin
Healthcare Provider Resources on Herbimycin	Symptoms of Herbimycin • Causes & Risk Factors for Herbimycin • Diagnostic studies for Herbimycin • Treatment of Herbimycin
Continuing Medical Education (CME) Programs on Herbimycin	CME Programs on Herbimycin
International Resources on Herbimycin	Herbimycin en Espanol • Herbimycin en Francais
Business Resources on Herbimycin	Herbimycin in the Marketplace • Patents on Herbimycin
Informatics Resources on Herbimycin	List of terms related to Herbimycin

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .