Haemorrhagic disease of the newborn

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Haemorrhagic disease of the newborn Classification and external resources
Vitamin K1
ICD-10	P53.
ICD-9	776.0
DiseasesDB	29544
eMedicine	ped/966
MeSH	D006475

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Overview

Haemorrhagic disease of the newborn is a coagulation disturbance in newborns due to vitamin K deficiency. As a consequence of vitamin K deficiency there is an impaired production of coagulation factors II, VII, IX, X, C and S by the liver.

Causes

Newborns are relatively vitamin K deficient for a variety of reasons. They have low vitamin K stores at birth, vitamin K passes the placenta poorly, the levels of vitamin K in breast milk are low and the gut flora has not yet been developed (vitamin K is normally produced by bacteria in the intestines).

Presentation

The disease causes an increased risk of bleeding. The most common sites of bleeding are the umbilicus, mucous membranes, gastrointestinal tract, circumcision and venipunctures.

Treatment

Treatment consists of vitamin K supplementation. This is often given prophylactically newborns shortly after birth.

v • d • e Certain conditions originating in the perinatal period (P, 760-779)
Maternal factors and complications	Umbilical cord prolapse - Nuchal cord - Chorioamnionitis
Length of gestation and fetal growth	Small for gestational age - Large for gestational age - Premature birth - Postmature birth
Birth trauma	Cephalhematoma - Brachial plexus lesion (Erb's palsy, Klumpke paralysis)
Respiratory	Intrauterine hypoxia - Infant respiratory distress syndrome - Transient tachypnea of the newborn - Meconium aspiration syndrome - pleural disease (Pneumothorax, Pneumomediastinum) - Wilson-Mikity syndrome - Bronchopulmonary dysplasia
Cardiovascular	Pneumopericardium - Persistent fetal circulation
Haemorrhagic and haematological/ hematologic disease	Haemorrhagic disease of the newborn - Hemolytic disease of the newborn - Rh disease - Hydrops fetalis - Hyperbilirubinemia (Kernicterus, Neonatal jaundice)
Digestive system	Ileus - Necrotizing enterocolitis
Integument and temperature regulation	Erythema toxicum
Other disorders	Periventricular leukomalacia - Gray baby syndrome - muscle tone (Congenital hypertonia, Congenital hypotonia) - Perinatal infection (Congenital rubella syndrome) - Velamentous cord insertion - Omphalitis

v • d • e WikiDoc Research Resources for Haemorrhagic disease of the newborn
Articles on Haemorrhagic disease of the newborn	Most recent articles on Haemorrhagic disease of the newborn • Most cited articles on Haemorrhagic disease of the newborn • Review articles on Haemorrhagic disease of the newborn • Articles on Haemorrhagic disease of the newborn in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Haemorrhagic disease of the newborn	Powerpoint slides on Haemorrhagic disease of the newborn • Images of Haemorrhagic disease of the newborn • Photos of Haemorrhagic disease of the newborn • Podcasts & MP3s on Haemorrhagic disease of the newborn • Videos on Haemorrhagic disease of the newborn
Evidence Based Medicine Regarding Haemorrhagic disease of the newborn	Cochrane Collaboration on Haemorrhagic disease of the newborn • Bandolier on Haemorrhagic disease of the newborn • TRIP on Haemorrhagic disease of the newborn
Cost Effectiveness of Haemorrhagic disease of the newborn	Cost Effectiveness of Haemorrhagic disease of the newborn
Clinical Trials Involving Haemorrhagic disease of the newborn	Ongoing Trials on Haemorrhagic disease of the newborn at Clinical Trials.gov • Trial results on Haemorrhagic disease of the newborn • Clinical Trials on Haemorrhagic disease of the newborn at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Haemorrhagic disease of the newborn	US National Guidelines Clearinghouse on Haemorrhagic disease of the newborn • NICE Guidance on Haemorrhagic disease of the newborn • NHS PRODIGY Guidance • FDA on Haemorrhagic disease of the newborn • CDC on Haemorrhagic disease of the newborn
Textbook Information on Haemorrhagic disease of the newborn	Books and Textbook Information on Haemorrhagic disease of the newborn
Pharmacology Resources on Haemorrhagic disease of the newborn	Dosing of Haemorrhagic disease of the newborn • Drug interactions with Haemorrhagic disease of the newborn • Side effects of Haemorrhagic disease of the newborn • Allergic reactions to Haemorrhagic disease of the newborn • Overdose information on Haemorrhagic disease of the newborn • Carcinogenicity information on Haemorrhagic disease of the newborn • Haemorrhagic disease of the newborn in pregnancy • Pharmacokinetics of Haemorrhagic disease of the newborn •
Genetics, Pharmacogenomics, and Proteinomics of Haemorrhagic disease of the newborn	Genetics of Haemorrhagic disease of the newborn • Pharmacogenomics of Haemorrhagic disease of the newborn • Proteomics of Haemorrhagic disease of the newborn
Newstories on Haemorrhagic disease of the newborn	Haemorrhagic disease of the newborn in the news • Be alerted to news on Haemorrhagic disease of the newborn • News trends on Haemorrhagic disease of the newborn
Commentary on Haemorrhagic disease of the newborn	Blogs on Haemorrhagic disease of the newborn
Patient Resources on Haemorrhagic disease of the newborn	Patient resources on Haemorrhagic disease of the newborn • Discussion groups on Haemorrhagic disease of the newborn • Patient Handouts on Haemorrhagic disease of the newborn • Directions to Hospitals Treating Haemorrhagic disease of the newborn • Risk calculators and risk factors for Haemorrhagic disease of the newborn
Healthcare Provider Resources on Haemorrhagic disease of the newborn	Symptoms of Haemorrhagic disease of the newborn • Causes & Risk Factors for Haemorrhagic disease of the newborn • Diagnostic studies for Haemorrhagic disease of the newborn • Treatment of Haemorrhagic disease of the newborn
Continuing Medical Education (CME) Programs on Haemorrhagic disease of the newborn	CME Programs on Haemorrhagic disease of the newborn
International Resources on Haemorrhagic disease of the newborn	Haemorrhagic disease of the newborn en Espanol • Haemorrhagic disease of the newborn en Francais
Business Resources on Haemorrhagic disease of the newborn	Haemorrhagic disease of the newborn in the Marketplace • Patents on Haemorrhagic disease of the newborn
Informatics Resources on Haemorrhagic disease of the newborn	List of terms related to Haemorrhagic disease of the newborn

de:Morbus haemorrhagicus neonatorum