Guanylate cyclase activator 2B

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Guanylate cyclase activator 2B is a protein that in humans is encoded by the GUCA2B gene.

Function

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys.

Further reading

• Sindić A, Hirsch JR, Velic A, Piechota H, Schlatter E (2005). "Guanylin and uroguanylin regulate electrolyte transport in isolated human cortical collecting ducts". Kidney Int. 67 (4): 1420–7. doi:10.1111/j.1523-1755.2005.00219.x. PMID 15780094.
• Guo HF, Gao PJ, Li Y, Zhu DL, Wang JG (2007). "[Association between uroguanylin G-247A polymorphism and blood pressure/fluid and electrolytes homeostasis]". Zhonghua Xin Xue Guan Bing Za Zhi (in Chinese). 35 (3): 233–6. PMID 17582287.CS1 maint: Unrecognized language (link)
• Yoshikawa Y, Nakayama T, Saito K, Hui P, Morita A, Sato N, Takahashi T, Tamura M, Sato I, Aoi N, Doba N, Hinohara S, Soma M, Usami R (2007). "Haplotype-based case-control study of the association between the guanylate cyclase activator 2B (GUCA2B, Uroguanylin) gene and essential hypertension". Hypertens. Res. 30 (9): 789–96. doi:10.1291/hypres.30.789. PMID 18037771.
• Yoshikawa Y, Nakayama T, Saito K, Hui P, Morita A, Sato N, Takahashi T, Tamura M, Sato I, Aoi N, Doba N, Hinohara S, Soma M, Usami R (2007). "Haplotype-based case-control study of the association between the guanylate cyclase activator 2B (GUCA2B, Uroguanylin) gene and essential hypertension". Hypertens. Res. 30 (9): 789–96. doi:10.1291/hypres.30.789. PMID 18037771.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.