Gonadoblastoma (patient information)

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Gonadoblastoma

Overview

What are the symptoms?

What are the causes?

Who is at highest risk?

Diagnosis

When to seek urgent medical care?

Treatment options

Where to find medical care for Gonadoblastoma?

Prevention

What to expect (Outlook/Prognosis)?

Possible complications

Gonadoblastoma On the Web

Ongoing Trials at Clinical Trials.gov

Images of Gonadoblastoma

Videos on Gonadoblastoma

FDA on Gonadoblastoma

CDC on Gonadoblastoma

Gonadoblastoma in the news

Blogs on Gonadoblastoma

Directions to Hospitals Treating Gonadoblastoma

Risk calculators and risk factors for Gonadoblastoma

For the WikiDoc page for this topic, click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]

Overview

Gonadoblastoma is a rare tumor of the gonads. It is an admixture of two types of cells, premature germ cells, and sex-cord stromal-like cells.

What are the Symptoms of Gonadoblastoma?

Gonadoblastoma has no specific signs and symptoms. It is a tumor usually arising from a maldeveloped gonad and it can manifest with non-specific symptoms such as:

It may also present as a lower abdominal mass in women or growing mass in the testicles causing discomfort in men.

What Causes gonadoblastoma?

  • The exact cause of gonadoblastoma is not clear, but it usually arises in the setting of maldeveloped sex organs.
  • There is also a hypothesis regarding the presence of a putative gene called TSPY gene. Although the exact mechanism of its role in the pathogenesis of the disease is not clear, it has been observed that the product of this gene increased in the gonadoblastoma.

Who is at Highest Risk?

Diagnosis

There is no single diagnostic tool for the diagnosis of gonadoblastoma. However, any individual with sex organ maldevelopment disorder is suspected of having gonadoblastoma and should be considered for a complete workup to diagnose the underlying disorder and should also be monitored by imaging studies for the presence or this tumor.

When to Seek Urgent Medical Care?

Individuals with a known diagnosis of sexual maldevelopment disorders such as:

should be screened for the presence of gonadoblastoma.

Treatment Options

Where to find Medical Care for Gonadoblastoma?

Medical care for gonadoblastoma can be found here.

Prevention

Gonadoblastoma is not preventable.

What to Expect (Outlook/Prognosis)?

Possible Complications

Gonadoblastoma can be complicated by conversion to dysgerminoma, a malignant tumor, and/or other malignant gonadal tumors.

Sources

http://www.nlm.nih.gov/medlineplus/ency/article/000434.htm


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