Glycine transaminase

In enzymology, a glycine transaminase (EC 2.6.1.4) is an enzyme that catalyzes the chemical reaction

glycine + 2-oxoglutarate <math>\rightleftharpoons</math> glyoxylate + L-glutamate

Thus, the two substrates of this enzyme are glycine and 2-oxoglutarate, whereas its two products are glyoxylate and L-glutamate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is glycine:2-oxoglutarate aminotransferase. Other names in common use include glutamic-glyoxylic transaminase, glycine aminotransferase, glyoxylate-glutamic transaminase, L-glutamate:glyoxylate aminotransferase, and glyoxylate-glutamate aminotransferase. This enzyme participates in glycine, serine and threonine metabolism. It employs one cofactor, pyridoxal phosphate.

References

IUBMB entry for 2.6.1.4
BRENDA references for 2.6.1.4 (Recommended.)
PubMed references for 2.6.1.4
PubMed Central references for 2.6.1.4
Google Scholar references for 2.6.1.4
Nakada HI (1964). "Glutamic-glycine transaminase from rat liver". J. Biol. Chem. 239: 468–471.
Thompson JS and Richardson KE (1966). "Isolation and chracterization of a glutamate-glycine transaminase from human liver". Arch. Biochem. Biophys. 117: 599–603.