Glucose-1-phosphate

Glucose-1-phosphate
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Identifiers
CAS number	59-56-3
PubChem	65533
MeSH	glucose-1-phosphate
Properties
Molecular formula	C6H13O9P
Molar mass	260.136
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Glucose 1-phosphate (also called cori ester) is a glucose molecule with a phosphate group on the 1'-carbon.

Reactions

Catabolic

In glycogenolysis, it is the direct product of the reaction in which glycogen phosphorylase cleaves off a molecule of glucose from a greater glycogen structure.

To be utilized in cellular catabolism it must first be converted to glucose 6-phosphate by the enzyme phosphoglucomutase. One reason that cells form glucose-1-phosphate instead of glucose during glycogen breakdown is that the very polar phosphorylated glucose cannot leave the cell mebrane and so is marked for intracellular catabolism.

Anabolic

In glycogenesis, free glucose 1-phosphate can also react with UTP to form UDP-glucose, by using the enzyme UDP-glucose pyrophosphorylase. It can then return to the greater glycogen structure via glycogen synthase.

See also

• Pentose phosphate pathway