Gemeprost

Gemeprost

Clinical data
Synonyms	methyl (E)-7-[(1R,2S,3R)-3-hydroxy-2-[(E,3R)-3-hydroxy-4,4-dimethyl-oct-1-enyl]-5-oxo-cyclopentyl]hept-2-enoate
AHFS/Drugs.com	International Drug Names
Routes of administration	Pessary
ATC code	G02AD03 (WHO)
Identifiers
IUPAC name methyl (2E,11α,13E,15R)-11,15-dihydroxy-16,16-dimethyl-9-oxoprosta-2,13-dien-1-oate
CAS Number	64318-79-2 Y
PubChem CID	5282237
DrugBank	DB08964 N
ChemSpider	4445416 Y
UNII	45KZB1FOLS
KEGG	D02073 Y
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C23H38O5
Molar mass	394.545 g/mol
3D model (JSmol)	Interactive image
SMILES O=C1C[C@@H](O)[C@H](/C=C/[C@@H](O)C(C)(C)CCCC)[C@H]1CCCC\C=C\C(=O)OC
InChI InChI=1S/C23H38O5/c1-5-6-15-23(2,3)21(26)14-13-18-17(19(24)16-20(18)25)11-9-7-8-10-12-22(27)28-4/h10,12-14,17-18,20-21,25-26H,5-9,11,15-16H2,1-4H3/b12-10+,14-13+/t17-,18-,20-,21-/m1/s1 Y Key:KYBOHGVERHWSSV-VNIVIJDLSA-N Y
NY (what is this?)  (verify)

WikiDoc Resources for Gemeprost
Articles
Most recent articles on Gemeprost Most cited articles on Gemeprost Review articles on Gemeprost Articles on Gemeprost in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Gemeprost Images of Gemeprost Photos of Gemeprost Podcasts & MP3s on Gemeprost Videos on Gemeprost
Evidence Based Medicine
Cochrane Collaboration on Gemeprost Bandolier on Gemeprost TRIP on Gemeprost
Clinical Trials
Ongoing Trials on Gemeprost at Clinical Trials.gov Trial results on Gemeprost Clinical Trials on Gemeprost at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Gemeprost NICE Guidance on Gemeprost NHS PRODIGY Guidance FDA on Gemeprost CDC on Gemeprost
Books
Books on Gemeprost
News
Gemeprost in the news Be alerted to news on Gemeprost News trends on Gemeprost
Commentary
Blogs on Gemeprost
Definitions
Definitions of Gemeprost
Patient Resources / Community
Patient resources on Gemeprost Discussion groups on Gemeprost Patient Handouts on Gemeprost Directions to Hospitals Treating Gemeprost Risk calculators and risk factors for Gemeprost
Healthcare Provider Resources
Symptoms of Gemeprost Causes & Risk Factors for Gemeprost Diagnostic studies for Gemeprost Treatment of Gemeprost
Continuing Medical Education (CME)
CME Programs on Gemeprost
International
Gemeprost en Espanol Gemeprost en Francais
Business
Gemeprost in the Marketplace Patents on Gemeprost
Experimental / Informatics
List of terms related to Gemeprost

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Gemeprost (16, 16-dimethyl-trans-delta2 PGE₁ methyl ester) is an analogue of prostaglandin E₁.

Clinical use

It is used as a treatment for obstetric bleeding.

It is used with mifepristone to terminate pregnancy up to 24 weeks gestation.

Side effects

Vaginal bleeding, cramps, nausea, vomiting, loose stools or diarrhea, headache, muscle weakness; dizziness; flushing; chills; backache; dyspnoea; chest pain; palpitations and mild pyrexia. Rare: Uterine rupture, severe hypotension, coronary spasms with subsequent myocardial infarctions.