The Gattermann-Koch reaction, named for the German chemists Ludwig Gattermann and Julius Arnold Koch, in organic chemistry refers to a Friedel-Crafts acylation reaction in which carbon monoxide and hydrochloric acid are used in-situ with Friedel-Crafts catalyst, namely AlCl3 to produce a benzaldehyde-derivative from a benzene-derivative in one step. Benzaldehyde and many aromatic aldehydes are conveniently synthesized by this reaction. Presence of traces of copper(I) chloride are also needed.
- Gattermann, L.; Koch, J. A. (1897). "Eine Synthese aromatischer Aldehyde". Ber. 30. doi:10.1002/cber.18970300288.
- LI Jie Jack (2003). Name Reactions: A Collection of Detailed Reaction Mechanisms (available on Google Books), 2nd edition, Springer, 157. ISBN 3540402039.