Gastric chief cell
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| Gastric chief cell | |
|---|---|
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| H&E stain of fundic gland polyp showing shortening of the gastric pits with cystic dilatation | |
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| A fundus gland. A. Transverse section of gland. | |
| Dorlands/Elsevier | c_18/12222877 |
Overview
A gastric chief cell (or peptic cell, or gastric zymogenic cell) is a cell in the stomach that releases pepsinogen, gastric lipase and rennin. The cell stains basophilic upon H&E prep due to the large proportion of rough endoplasmic reticulum in it's cytoplasm.
It works in conjunction with the parietal cell which releases gastric acid, converting the pepsinogen into pepsin.
Nomenclature
The terms "chief cell" and "zymogenic cell" are often used without the word "gastric" to name this type of cell. However those terms can also be used to describe other cell types (for example, parathyroid chief cells).
See also
External links
- Anatomy Atlases - Microscopic Anatomy, plate 01.05
- Histology at Boston University 22201loa - "Ultrastructure of the Cell: chief cells and enteroendocrine cell"
- Histology at Boston University 11304loa - "Digestive System: Alimentary Canal: fundic stomach, gastric glands, base"
- c_18/12224535 at Dorland's Medical Dictionary
- Physiology at MCG 6/6ch4/s6ch4_8
Digestive system, physiology: gastrointestinal physiology | |
|---|---|
| Enteric nervous system | Meissner's plexus - Auerbach's plexus |
| Exocrine | Chief cells (Pepsinogen) - Parietal cells (Gastric acid, Intrinsic factor) - Goblet cells (Mucus) |
| Endocrine/paracrine | G cells (gastrin), D cells (somatostatin) - ECL cells (Histamine) - enterogastrone: I cells (CCK), K cells (GIP), S cells (secretin) |
| Border | Brunner's glands - Paneth cells - Enterocytes |
| Fluids | Saliva - Bile - Intestinal juice - Gastric juice - Pancreatic juice |
| Processes | Swallowing - Vomiting - Peristalsis (Interstitial cell of Cajal) - Migrating motor complex - Borborygmus - Gastrocolic reflex - Segmentation contractions - Defecation |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
