Fructose-2,6-bisphosphatase is an enzyme that catalyzes the following reaction:
- Fructose 2,6-bisphosphate.svg
Fructose-2,6-bisphosphatase is important in regulation of gluconeogenesis & glycolysis as it catalyzes the dephosphorylation of fructose-2,6-bisphosphate. Because fructose-2,6-bisphosphate activates phosphofructokinase-1 (a critical enzyme in glycolysis) and inhibits fructose-1,6-bisphosphatase (a critical enzyme in gluconeogenesis), the activity of fructose-2,6-bisphosphatase decreases glycolysis and increases gluconeogenesis.
Fructose-2,6-bisphosphatase is subject to product inhibition by fructose-6-phosphate. Fructose-2,6-bisphosphatase also undergoes addition of a phosphate group to a single serine residue by cAMP-dependent protein kinase (known as covalent modification), which activates (increases catalytic activity) of Fructose-2,6-bisphosphatase.
Hydrolase: esterases (EC 3.1)
|3.1.1: Carboxylic ester hydrolases||Cholinesterase - Pectinesterase - 6-phosphogluconolactonase - PAF acetylhydrolase Phospholipase (A1, A2, B)|
|3.1.2: Thioesterase||Palmitoyl thioesterase - Ubiquitin carboxy-terminal hydrolase L1|
|3.1.3: Phosphatase||Alkaline phosphatase - Acid phosphatase (Prostatic)/Tartrate resistant acid phosphatase/Purple acid phosphatases - Nucleotidase - Glucose 6-phosphatase - Fructose 1,6-bisphosphatase - Calcineurin - Phosphoprotein phosphatase (PP2A) - OCRL - Pyruvate dehydrogenase phosphatase - Fructose 2,6-bisphosphatase - Protein tyrosine phosphatase - PTEN|
|3.1.4: Phosphodiesterase||Autotaxin - Phospholipase (C, D) - Sphingomyelin phosphodiesterase - PDE1 - PDE2 - PDE3 - PDE5|
|3.1.6: Sulfatase||Arylsulfatase B - Steroid sulfatase - Galactosamine-6 sulfatase - Arylsulfatase A - Iduronate-2-sulfatase - N-acetylglucosamine-6-sulfatase|
Carbohydrate metabolism: glycolysis/gluconeogenesis enzymes
|Glycolysis||Glucokinase/Hexokinase/Glucose 6-phosphatase - Glucose isomerase - Phosphofructokinase 1/Fructose 1,6-bisphosphatase - Aldolase - Triosephosphate isomerase - Glyceraldehyde 3-phosphate dehydrogenase - Phosphoglycerate kinase - Phosphoglycerate mutase - Enolase - Pyruvate kinase|
|Gluconeogenesis only||Pyruvate carboxylase - Phosphoenolpyruvate carboxykinase - from lactate (Cori cycle): Lactate dehydrogenase - from alanine (Alanine cycle): Alanine transaminase|
|Regulatory||Phosphofructokinase 2/Fructose 2,6-bisphosphatase - Bisphosphoglycerate mutase|
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