Foldamers

Jump to: navigation, search
Crystal structure of a foldmer reported by Lehn and coworkers in Helv. Chim. Acta., 2003, 86, 1598-1624.

WikiDoc Resources for Foldamers

Articles

Most recent articles on Foldamers

Most cited articles on Foldamers

Review articles on Foldamers

Articles on Foldamers in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Foldamers

Images of Foldamers

Photos of Foldamers

Podcasts & MP3s on Foldamers

Videos on Foldamers

Evidence Based Medicine

Cochrane Collaboration on Foldamers

Bandolier on Foldamers

TRIP on Foldamers

Clinical Trials

Ongoing Trials on Foldamers at Clinical Trials.gov

Trial results on Foldamers

Clinical Trials on Foldamers at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Foldamers

NICE Guidance on Foldamers

NHS PRODIGY Guidance

FDA on Foldamers

CDC on Foldamers

Books

Books on Foldamers

News

Foldamers in the news

Be alerted to news on Foldamers

News trends on Foldamers

Commentary

Blogs on Foldamers

Definitions

Definitions of Foldamers

Patient Resources / Community

Patient resources on Foldamers

Discussion groups on Foldamers

Patient Handouts on Foldamers

Directions to Hospitals Treating Foldamers

Risk calculators and risk factors for Foldamers

Healthcare Provider Resources

Symptoms of Foldamers

Causes & Risk Factors for Foldamers

Diagnostic studies for Foldamers

Treatment of Foldamers

Continuing Medical Education (CME)

CME Programs on Foldamers

International

Foldamers en Espanol

Foldamers en Francais

Business

Foldamers in the Marketplace

Patents on Foldamers

Experimental / Informatics

List of terms related to Foldamers

Overview

A foldamer is a discrete chain molecule or oligomer that adopts a secondary structure stabilized by non-covalent interactions [1] [2]. They are artificial molecules that mimic the ability of proteins, nucleic acids, and polysaccharides to fold into well-defined conformations, such as helices and β-sheets. Foldamers have been demonstrated to display a number of interesting supramolecular properties including molecular self-assembly, molecular recognition, and host-guest chemistry. They are studied as models of biological molecules and have been shown to display antimicrobial activity. They also have great potential application to the development of new functional materials.

Examples:

  • m-Phenylene ethynylene oligomers are driven to fold into a helical conformation by solvophobic forces and aromatic stacking interactions.
  • β-peptides are composed of amino acids containing an additional methylene unit between the amine and carboxylic acid. They are more stable to enzymatic degradation and have been demonstrated to have antimicrobial activity.
  • Aedamers that fold in aqueous solutions driven by hydrophobic and aromatic stacking interactions.

References

Important Reviews:

  1. ^ Gellman, S.H. (1998). "Foldamers: a manifesto" (PDF). Acc. Chem. Res. 31 (4): 173–180. doi:10.1021/ar960298r.
  2. ^ Hill DJ, Mio MJ, Prince RB, Hughes TS, Moore JS (2001). "A field guide to foldamers". Chem. Rev. 101 (12): 3893–4012. doi:10.1021/cr990120t. PMID 11740924.

Further reading

External links

  • "Moore Research Group". Developed m-Phenylene ethynylene oligomers. Retrieved October 15. Unknown parameter |accessyear= ignored (|access-date= suggested) (help); Check date values in: |accessdate= (help)
  • "Gellman Research Group". Developed a number of β-peptides and has explored their antimicrobial activity. Retrieved October 15. Unknown parameter |accessyear= ignored (|access-date= suggested) (help); Check date values in: |accessdate= (help)
  • "Iverson Research Group". Developed aedamers that fold in aqueous solutions. Retrieved October 15. Unknown parameter |accessyear= ignored (|access-date= suggested) (help); Check date values in: |accessdate= (help)



Linked-in.jpg