Fludrocortisone

Fludrocortisone
Systematic (IUPAC) name
9-fluoro-11,17-dihydroxy-17- (2-hydroxyacetyl)- 10,13-dimethyl- 1,2,6,7,8,9,10,11,12, 13,14,15,16,17- tetradecahydrocyclopenta[a]phenanthren-3-one
Identifiers
CAS number	127-31-1
ATC code	H02AA02
PubChem	31378
DrugBank	APRD00756
Chemical data
Formula	C21H29FO5
Mol. mass	380.45 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	High
Metabolism	Hepatic
Half life	3.5 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	C
Legal status
Routes	oral

WikiDoc Resources for Fludrocortisone
Articles
Most recent articles on Fludrocortisone Most cited articles on Fludrocortisone Review articles on Fludrocortisone Articles on Fludrocortisone in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Fludrocortisone Images of Fludrocortisone Photos of Fludrocortisone Podcasts & MP3s on Fludrocortisone Videos on Fludrocortisone
Evidence Based Medicine
Cochrane Collaboration on Fludrocortisone Bandolier on Fludrocortisone TRIP on Fludrocortisone
Clinical Trials
Ongoing Trials on Fludrocortisone at Clinical Trials.gov Trial results on Fludrocortisone Clinical Trials on Fludrocortisone at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Fludrocortisone NICE Guidance on Fludrocortisone NHS PRODIGY Guidance FDA on Fludrocortisone CDC on Fludrocortisone
Books
Books on Fludrocortisone
News
Fludrocortisone in the news Be alerted to news on Fludrocortisone News trends on Fludrocortisone
Commentary
Blogs on Fludrocortisone
Definitions
Definitions of Fludrocortisone
Patient Resources / Community
Patient resources on Fludrocortisone Discussion groups on Fludrocortisone Patient Handouts on Fludrocortisone Directions to Hospitals Treating Fludrocortisone Risk calculators and risk factors for Fludrocortisone
Healthcare Provider Resources
Symptoms of Fludrocortisone Causes & Risk Factors for Fludrocortisone Diagnostic studies for Fludrocortisone Treatment of Fludrocortisone
Continuing Medical Education (CME)
CME Programs on Fludrocortisone
International
Fludrocortisone en Espanol Fludrocortisone en Francais
Business
Fludrocortisone in the Marketplace Patents on Fludrocortisone
Experimental / Informatics
List of terms related to Fludrocortisone

Fludrocortisone is a synthetic corticosteroid with moderate glucocorticoid potency and much greater mineralocorticoid potency. It is used primarily to replace the missing hormone aldosterone in various forms of adrenal insufficiency such as Addison's disease and the classic salt wasting (21-hydroxylase deficiency) form of congenital adrenal hyperplasia. It is occasionally used to treat orthostatic hypotension as well.

The brand name in the U.S. is Florinef. It is available in 0.1 mg tablets. Typical daily doses for mineralocorticoid replacement are between 0.05 mg - 0.2 mg. Renin plasma, sodium, and potassium is checked through blood tests in order to verify that the correct dosage is reached.

Chemically, its structure is identical to cortisone except for the substitution of F in place of one hydrogen. F is a good bioisostere for hydrogen because it is similar in size. The major difference is in its electronegativity.