Fludrocortisone

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Fludrocortisone
Systematic (IUPAC) name
9-fluoro-11,17-dihydroxy-17- (2-hydroxyacetyl)- 10,13-dimethyl- 1,2,6,7,8,9,10,11,12, 13,14,15,16,17- tetradecahydrocyclopenta[a]phenanthren-3-one
Identifiers
CAS number	127-31-1
ATC code	H02AA02
PubChem	31378
DrugBank	APRD00756
Chemical data
Formula	C21H29FO5
Mol. mass	380.45 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	High
Metabolism	Hepatic
Half life	3.5 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	C
Legal status
Routes	oral

WikiDoc Resources for Fludrocortisone
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Evidence Based Medicine
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Clinical Trials
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Guidelines / Policies / Govt
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Commentary
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Definitions
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Patient Resources / Community
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Healthcare Provider Resources
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Continuing Medical Education (CME)
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International
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Business
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Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch. Fludrocortisone is a synthetic corticosteroid with moderate glucocorticoid potency and much greater mineralocorticoid potency. It is used primarily to replace the missing hormone aldosterone in various forms of adrenal insufficiency such as Addison's disease and the classic salt wasting (21-hydroxylase deficiency) form of congenital adrenal hyperplasia. It is occasionally used to treat orthostatic hypotension as well.

The brand name in the U.S. is Florinef. It is available in 0.1 mg tablets. Typical daily doses for mineralocorticoid replacement are between 0.05 mg - 0.2 mg. Renin plasma, sodium, and potassium is checked through blood tests in order to verify that the correct dosage is reached.

Chemically, its structure is identical to cortisone except for the substitution of F in place of one hydrogen. F is a good bioisostere for hydrogen because it is similar in size. The major difference is in its electronegativity.

v • d • e WikiDoc Research Resources for Fludrocortisone
Articles on Fludrocortisone	Most recent articles on Fludrocortisone • Most cited articles on Fludrocortisone • Review articles on Fludrocortisone • Articles on Fludrocortisone in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Fludrocortisone	Powerpoint slides on Fludrocortisone • Images of Fludrocortisone • Photos of Fludrocortisone • Podcasts & MP3s on Fludrocortisone • Videos on Fludrocortisone
Evidence Based Medicine Regarding Fludrocortisone	Cochrane Collaboration on Fludrocortisone • Bandolier on Fludrocortisone • TRIP on Fludrocortisone
Cost Effectiveness of Fludrocortisone	Cost Effectiveness of Fludrocortisone
Clinical Trials Involving Fludrocortisone	Ongoing Trials on Fludrocortisone at Clinical Trials.gov • Trial results on Fludrocortisone • Clinical Trials on Fludrocortisone at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Fludrocortisone	US National Guidelines Clearinghouse on Fludrocortisone • NICE Guidance on Fludrocortisone • NHS PRODIGY Guidance • FDA on Fludrocortisone • CDC on Fludrocortisone
Textbook Information on Fludrocortisone	Books and Textbook Information on Fludrocortisone
Pharmacology Resources on Fludrocortisone	Dosing of Fludrocortisone • Drug interactions with Fludrocortisone • Side effects of Fludrocortisone • Allergic reactions to Fludrocortisone • Overdose information on Fludrocortisone • Carcinogenicity information on Fludrocortisone • Fludrocortisone in pregnancy • Pharmacokinetics of Fludrocortisone •
Genetics, Pharmacogenomics, and Proteinomics of Fludrocortisone	Genetics of Fludrocortisone • Pharmacogenomics of Fludrocortisone • Proteomics of Fludrocortisone
Newstories on Fludrocortisone	Fludrocortisone in the news • Be alerted to news on Fludrocortisone • News trends on Fludrocortisone
Commentary on Fludrocortisone	Blogs on Fludrocortisone
Patient Resources on Fludrocortisone	Patient resources on Fludrocortisone • Discussion groups on Fludrocortisone • Patient Handouts on Fludrocortisone • Directions to Hospitals Treating Fludrocortisone • Risk calculators and risk factors for Fludrocortisone
Healthcare Provider Resources on Fludrocortisone	Symptoms of Fludrocortisone • Causes & Risk Factors for Fludrocortisone • Diagnostic studies for Fludrocortisone • Treatment of Fludrocortisone
Continuing Medical Education (CME) Programs on Fludrocortisone	CME Programs on Fludrocortisone
International Resources on Fludrocortisone	Fludrocortisone en Espanol • Fludrocortisone en Francais
Business Resources on Fludrocortisone	Fludrocortisone in the Marketplace • Patents on Fludrocortisone
Informatics Resources on Fludrocortisone	List of terms related to Fludrocortisone

v • d • e Corticosteroids - glucocorticoid/receptor and mineralocorticoid/receptor (A07EA, C05AA, D07, D10AA, H02, R01AD, R03BA, S01BA, S02B, and S03B)
Endogenous	Aldosterone, Cortisone, Hydrocortisone/cortisol, Desoxycortone
Others	Alclometasone, Amcinonide, Beclometasone, Betamethasone, Budesonide, Ciclesonide, Clobetasol, Clobetasone, Clocortolone, Cloprednol, Cortivazol, Deflazacort, Deoxycorticosterone, Desonide, Desoximetasone, Dexamethasone, Diflorasone, Diflucortolone, Difluprednate, Fluclorolone, Fludrocortisone, Fludroxycortide, Flumetasone, Flunisolide, Fluocinolone acetonide, Fluocinonide, Fluocortin, Fluocortolone, Fluorometholone, Fluperolone, Fluprednidene, Fluticasone, Formocortal, Halcinonide, Halometasone, Hydrocortisone aceponate, Hydrocortisone buteprate, Hydrocortisone butyrate, Loteprednol, Medrysone, Meprednisone, Methylprednisolone,Methylprednisolone aceponate, Mometasone furoate, Paramethasone, Prednicarbate, Prednisone, Prednisolone, Prednylidene, Rimexolone, Tixocortol, Triamcinolone, Ulobetasol

v • d • e Corticosteroids for systemic use (H02)
Mineralocorticoids	Aldosterone - Fludrocortisone - Desoxycortone
Glucocorticoids	Betamethasone - Dexamethasone - Fluocortolone - Methylprednisolone - Paramethasone - Prednisolone - Prednisone - Triamcinolone - Hydrocortisone - Cortisone - Prednylidene - Rimexolone - Deflazacort - Cloprednol - Meprednisone - Cortivazol
Anticorticosteroids	Trilostane