FYVE domain
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FYVE zinc finger domain is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1.
The FYVE finger binds two zinc ions. The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue. FYVE domains bind Phosphatidylinositol 3-phosphate.
The FYVE finger is structural similarity to RING domain and PHD finger.
External links
- FYVE domain in Pfam
- UMich Orientation of Proteins in Membranes families/superfamily-62 - Orientations of FYVE/PHD zinc finger domains in membranes (OPM)
Protein domains |
|---|
| BZIP - DED - Kringle - PH - SH2 - SH3 - zinc finger - FYVE - PX - ENTH - BAR - PDZ - CARD - SUN - TRIO - C1 - LIM - C2 |
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