Drotaverine
You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.
| Image:Drotaverine.svg | |
| Drotaverine
| |
| Systematic (IUPAC) name | |
| (1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7- diethoxy-3,4-dihydro-2H-isoquinoline | |
| Identifiers | |
| CAS number | |
| ATC code | A03 |
| PubChem | |
| Chemical data | |
| Formula | C24H31NO4 |
| Mol. mass | 397.507 g/mol |
| Pharmacokinetic data | |
| Bioavailability | Highly variable |
| Protein binding | 80 to 95% |
| Metabolism | Hepatic |
| Half life | 7 to 12 hours |
| Excretion | Fecal and renal |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | Oral, intravenous |
Drotaverine (INN, also known as drotaverin) is an antispasmodic drug, structurally related to papaverine. Drotaverine is a selective inhibitor of phosphodiesterase 4, and has no anticholinergic effects.
A small 2003 study found drotaverine to be nearly 80% effective in treating renal colic.[1] It has also been used to accelerate labor.[2]
References
- ↑ Romics I, Molnár DL, Timberg G, et al (2003). "The effect of drotaverine hydrochloride in acute colicky pain caused by renal and ureteric stones". BJU Int 92 (1): 92–6. doi:10.1046/j.1464-410X.2003.04262.x. PMID 12823389.
- ↑ Singh KC, Jain P, Goel N, Saxena A (2004). "Drotaverine hydrochloride for augmentation of labor". Int J Gynaecol Obstet 84 (1): 17–22. PMID 14698825.
Drugs for functional gastrointestinal disorders (A03) | |
|---|---|
| Drugs for functional bowel disorders | antimuscarinics: Mebeverine - Dicycloverine - Propantheline
papaverine and derivatives: Papaverine - Drotaverine - Moxaverine acting on serotonin receptors: 5-HT3 antagonists (Alosetron, Cilansetron) - 5HT4 agonists (Mosapride, Tegaserod) other: Diisopromine - Isometheptene - Phloroglucinol - Proglumide - Tridihexethyl |
| Belladonna and derivatives (antimuscarinics) | Atropine - Hyoscyamine - Butylscopolamine - Methylscopolamine |
| Propulsives | primarily dopamine antagonists (Metoclopramide/Bromopride, Domperidone, Alizapride) - serotonin agonists (Cisapride) - Clebopride |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
