Dilute Russell's viper venom time
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Dilute Russell's viper venom time (dRVVT) is a laboratory test often used for detection of lupus anticoagulant (LA). This in vitro diagnostic test is based on the ability of the venom of the Russell's viper to induce thrombosis. The coagulant in the venom directly activates factor X, which turns prothrombin into thrombin in the presence of factor V and phospholipid. In the dRVVT assay, low, rate-limiting concentrations of both Russell's viper venom and phospholipid are used to give a clotting time of 23 to 27 seconds. This makes the test sensitive to the presence of lupus anticoagulants, since these antibodies interfere with the clot-promoting role of phospholipid in vitro.[1] The inhibitory effect of LA on dRVVT can be overcome by adding an excess of phospholipid to the assay - this can be used as a specificity control to confirm the diagnosis, as are mixing studies, which confirm that clot prolongation is due to an inhibitor, rather than a factor deficiency. The dRVVT test is more sensitive than the aPTT test for the detection of lupus anticoagulant, because it is not influenced by deficiencies or inhibitors of clotting factors VIII, IX or XI.[1]
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Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
