Diabetic nephropathy causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2]

Overview

Diabetes mellitus both type1 and type 2 is the major cause. It is thought to be due to hyperfiltration through the renal glomeruli. The chances of developing diabetic nephropathy is markedly increased in patients with a diabetic sibling or parent who has diabetic nephropathy. these observations have been seen in both type 1 and type 2 diabetes. The genetic basis underlying the heritability of diabetic nephropathy is not known.

Causes

  • Diabetes, type 1 or 2
  • Persistent, uncontrolled hyperglycemia
  • Hypertension in the presence of diabetes.
  • Diabetes with smoking
  • High blood cholesterol and diabetes
  • Genetic factors

References[1]

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  1. Chang MS, Hsu YH (July 2018). "The role of IL-20 in chronic kidney disease and diabetic nephropathy: Pathogenic and therapeutic implications". J. Leukoc. Biol. doi:10.1002/JLB.MR1217-489R. PMID 29999545.