Class II PI 3-kinases
Class II PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain structure, substrate specificity and method of activation.
Class II PI 3-kinases were the most recently identified class of PI 3-kinases and little is currently known about these enzymes.
There are three class II PI 3-kinase isoforms expressed in mammalian cells;
- Stein RC( 2001) Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment Endocr Relat Cancer 8:237-248 
- Foster FM, Traer CJ, Abraham SM, and Fry MJ (2003) The phosphoinositide (PI) 3-kinase family J Cell Sci 116:3037-3040.
- Vanhaesebroeck B, Waterfield MD.(1999) Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res. 253(1):239-54.
Phosphotransferases/kinases (EC 2.7)
|2.7.1 - OH acceptor||Hexo- - Gluco- - Fructo- (Hepatic fructo-) - Galacto- - Phosphofructo- (1, 2) - Thymidine - NAD+ - Glycerol - Pantothenate - Mevalonate - Pyruvate - Deoxycytidine - PFP - Diacylglycerol - Bruton's tyrosine - Phosphoinositide 3 (Class I PI 3, Class II PI 3) - Sphingosine|
|2.7.2 - COOH acceptor||Phosphoglycerate - Aspartate|
|2.7.3 - N acceptor||Creatine|
|2.7.4 - PO4 acceptor||Phosphomevalonate - Adenylate - Nucleoside-diphosphate|
|2.7.6 - P2O7||Ribose-phosphate diphosphokinase - Thiamine pyrophosphokinase|
|2.7.7 - nucleotidyl-||Integrase - PNPase - Polymerase - RNase PH - UDP-glucose pyrophosphorylase - Galactose-1-phosphate uridylyltransferase -Terminal deoxynucleotidyl transferase - RNA replicase - Reverse transcriptase (Telomerase) - Transposase|
|2.7.8 - other phos.||N-acetylglucosamine-1-phosphate transferase|
|2.7.10-11 - protein||Tyrosine - Serine/threonine-specific|
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