Chronic bronchitis
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| Bronchitis Classification and external resources | |
| ICD-10 | J42. |
|---|---|
| ICD-9 | 491 |
| MeSH | D029481 |
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Overview
Bronchitis is an inflammation of the bronchi (medium-size airways) in the lungs. Acute bronchitis is usually caused by viruses or bacteria and may last several days or weeks. Chronic bronchitis is not necessarily caused by infection and is generally part of a syndrome called chronic obstructive pulmonary disease (COPD); it is defined clinically as a persistent cough that produces sputum (phlegm) and mucus, for at least three months in two consecutive years.
Signs and symptoms
Bronchitis may be indicated by an expectorating cough (also known as a productive cough, i.e. one that produces sputum), shortness of breath (dyspnea) and wheezing. Occasionally chest pains, fever, and fatigue or malaise may also occur. Mucus is normally green or yellowish green.
Diagnosis
A physical examination will often reveal decreased intensity of breath sounds, wheeze (rales) and prolonged expiration. Most doctors rely on the presence of a persistent dry or wet cough as evidence of bronchitis.
A variety of tests may be performed in patients presenting with cough and shortness of breath:
- Pulmonary Function Tests (PFT) (or spirometry) must be performed in all patients presenting with chronic cough. An FEV1/FVC ratio below 0.7 that is not fully reversible after bronchodilator therapy indicates the presence of COPD, that requires more aggressive therapy and carries a more severe prognosis than simple chronic bronchitis.
- A chest X-ray that reveals hyperinflation; collapse and consolidation of lung areas would support a diagnosis of pneumonia. Some conditions that predispose to bronchitis may be indicated by chest radiography.
- A sputum sample showing neutrophil granulocytes (inflammatory white blood cells) and culture showing that has pathogenic microorganisms such as Streptococcus spp.
- A blood test would indicate inflammation (as indicated by a raised white blood cell count and elevated C-reactive protein).
- Neutrophils infiltrate the lung tissue, aided by damage to the airways caused by irritation.
- Damage caused by irritation of the airways leads to inflammation and leads to neutrophils being present
- Mucosal hypersecretion is promoted by a substance released by neutrophils
- Further obstruction to the airways is caused by more goblet cells in the small airways. This is typical of chronic bronchitis
- Although infection is not the reason or cause of chronic bronchitis it is seen to aid in sustaining the bronchitis.
Treatment
Antibiotics
For acute exacerbations of chronic bronchitis, if antibiotics are used a meta-analysis found that "amoxicillin/clavulanic acid, macrolides, second-generation or third-generation cephalosporins, and quinolones" may be more effective.[1]
Bronchodilators
For acute exacerbations of chronic bronchitis, a clinical practice guideline by the American College of Physicians found that bronchodilators may help.[1]
Corticosteroids
For acute exacerbations of chronic bronchitis, a clinical practice guideline by the American College of Physicians found that corticosteroids may help.[1]
Smoking cessation
References
WikiDoc Research Resources for Chronic bronchitis | |
|---|---|
| Articles on Chronic bronchitis | Most recent articles on Chronic bronchitis • Most cited articles on Chronic bronchitis • Review articles on Chronic bronchitis • Articles on Chronic bronchitis in N Eng J Med, Lancet, BMJ |
| Media (Slides, Video, Images, MP3) on Chronic bronchitis | Powerpoint slides on Chronic bronchitis • Images of Chronic bronchitis • Photos of Chronic bronchitis • Podcasts & MP3s on Chronic bronchitis • Videos on Chronic bronchitis |
| Evidence Based Medicine Regarding Chronic bronchitis | Cochrane Collaboration on Chronic bronchitis • Bandolier on Chronic bronchitis • TRIP on Chronic bronchitis |
| Cost Effectiveness of Chronic bronchitis | Cost Effectiveness of Chronic bronchitis |
| Clinical Trials Involving Chronic bronchitis | Ongoing Trials on Chronic bronchitis at Clinical Trials.gov • Trial results on Chronic bronchitis • Clinical Trials on Chronic bronchitis at Google |
| Guidelines / Policies / Government Resources (FDA/CDC) Regarding Chronic bronchitis | US National Guidelines Clearinghouse on Chronic bronchitis • NICE Guidance on Chronic bronchitis • NHS PRODIGY Guidance • FDA on Chronic bronchitis • CDC on Chronic bronchitis |
| Textbook Information on Chronic bronchitis | Books and Textbook Information on Chronic bronchitis |
| Pharmacology Resources on Chronic bronchitis | Dosing of Chronic bronchitis • Drug interactions with Chronic bronchitis • Side effects of Chronic bronchitis • Allergic reactions to Chronic bronchitis • Overdose information on Chronic bronchitis • Carcinogenicity information on Chronic bronchitis • Chronic bronchitis in pregnancy • Pharmacokinetics of Chronic bronchitis • |
| Genetics, Pharmacogenomics, and Proteinomics of Chronic bronchitis | Genetics of Chronic bronchitis • Pharmacogenomics of Chronic bronchitis • Proteomics of Chronic bronchitis |
| Newstories on Chronic bronchitis | Chronic bronchitis in the news • Be alerted to news on Chronic bronchitis • News trends on Chronic bronchitis |
| Commentary on Chronic bronchitis | Blogs on Chronic bronchitis |
| Patient Resources on Chronic bronchitis | Patient resources on Chronic bronchitis • Discussion groups on Chronic bronchitis • Patient Handouts on Chronic bronchitis • Directions to Hospitals Treating Chronic bronchitis • Risk calculators and risk factors for Chronic bronchitis |
| Healthcare Provider Resources on Chronic bronchitis | Symptoms of Chronic bronchitis • Causes & Risk Factors for Chronic bronchitis • Diagnostic studies for Chronic bronchitis • Treatment of Chronic bronchitis |
| Continuing Medical Education (CME) Programs on Chronic bronchitis | CME Programs on Chronic bronchitis |
| International Resources on Chronic bronchitis | Chronic bronchitis en Espanol • Chronic bronchitis en Francais |
| Business Resources on Chronic bronchitis | Chronic bronchitis in the Marketplace • Patents on Chronic bronchitis |
| Informatics Resources on Chronic bronchitis | List of terms related to Chronic bronchitis |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
de:Chronische Bronchitiseu:Bronkitis kroniko lb:Bronchite (chronesch) sr:Хронични бронхитис
