Buflomedil

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Buflomedil

Names
IUPAC name 4-(pyrrolidin-1-yl)-1-(2,4,6-trimethoxyphenyl)butan-1-one
Identifiers
CAS Number	55837-25-7 Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL188921 Y
ChemSpider	2373 Y
ECHA InfoCard
PubChem CID	2467
InChI InChI=1S/C17H25NO4/c1-20-13-11-15(21-2)17(16(12-13)22-3)14(19)7-6-10-18-8-4-5-9-18/h11-12H,4-10H2,1-3H3 Y Key: OWYLAEYXIQKAOL-UHFFFAOYSA-N Y InChI=1/C17H25NO4/c1-20-13-11-15(21-2)17(16(12-13)22-3)14(19)7-6-10-18-8-4-5-9-18/h11-12H,4-10H2,1-3H3 Key: OWYLAEYXIQKAOL-UHFFFAOYAG
SMILES O=C(c1c(OC)cc(OC)cc1OC)CCCN2CCCC2
Properties
Chemical formula	C17H25NO4
Molar mass	307.38 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y verify (what is YN ?)
Infobox references

WikiDoc Resources for Buflomedil
Articles
Most recent articles on Buflomedil Most cited articles on Buflomedil Review articles on Buflomedil Articles on Buflomedil in N Eng J Med, Lancet, BMJ
Media
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Evidence Based Medicine
Cochrane Collaboration on Buflomedil Bandolier on Buflomedil TRIP on Buflomedil
Clinical Trials
Ongoing Trials on Buflomedil at Clinical Trials.gov Trial results on Buflomedil Clinical Trials on Buflomedil at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Buflomedil NICE Guidance on Buflomedil NHS PRODIGY Guidance FDA on Buflomedil CDC on Buflomedil
Books
Books on Buflomedil
News
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Commentary
Blogs on Buflomedil
Definitions
Definitions of Buflomedil
Patient Resources / Community
Patient resources on Buflomedil Discussion groups on Buflomedil Patient Handouts on Buflomedil Directions to Hospitals Treating Buflomedil Risk calculators and risk factors for Buflomedil
Healthcare Provider Resources
Symptoms of Buflomedil Causes & Risk Factors for Buflomedil Diagnostic studies for Buflomedil Treatment of Buflomedil
Continuing Medical Education (CME)
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International
Buflomedil en Espanol Buflomedil en Francais
Business
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Experimental / Informatics
List of terms related to Buflomedil

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Buflomedil is a vasoactive drug used to treat claudication or the symptoms of peripheral arterial disease. It is currently not approved by the Food and Drug Administration (FDA) for use in the United States. Currently available as trade name tablet Loftyl

Toxicity

This drug might be suspended from marketing in the European Union, because of concerns about severe neurological and cardiac toxicity. In its press release dated 17 November 2011 EMA suggested that doctors "should stop using buflomedil and consider alternative treatment options".

Various adverse effects have been reported to the FDA.