Boron Neutron Capture Therapy

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Overview

Boron neutron capture therapy (BNCT) is an experimental form of radiotherapy that utilizes a neutron beam that interacts with boron injected to a patient. BNCT depends on the interaction of slow neutrons with boron-10 to produce alpha particles and lithium nuclei, without producing other types of ionizing radiation. Patients are first given an intravenous injection of a boron-10 tagged chemical that preferentially binds to tumor cells. In clinical trials performed so far the neutrons are created in a nuclear reactor, but particle accelerators may also be used to collide protons into targets made of lithium or beryllium. The neutrons pass through a moderator, which shapes the neutron energy spectrum suitable for BNCT treatment. Before entering the patient the neutron beam is shaped by a beam collimator. While passing through the tissue of the patient, the neutrons are slowed by collisions and become low energy thermal neutrons. The thermal neutrons undergo reaction with the boron-10 nuclei, forming a compound nucleus (excited boron-11) which then promptly disintegrates to lithium-7 and an alpha particle. Both the alpha particle and the lithium ion produce closely spaced ionizations in the immediate vicinity of the reaction, with a range of approximately 10 micrometres, or one cell diameter. This technique is advantageous since the radiation damage occurs over a short range and thus normal tissues can be spared. BNCT has been experimentaly tested primarily as an alternative treatment for malignant brain tumors called glioblastomas. Although there are reports of some successful outcomes, this approach has not yet been shown to be superior to other current therapies. Hence, BNCT has not entered routine clinical use.

External links

• International Society of Neutron Capture therapy
• Helsinki University Central Hospital and Technical Research Centre of Finland BNCT Project

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Medicine	Imaging Positron emission tomography (PET) · Single photon emission computed tomography (SPECT) · Gamma (Anger) camera Therapies Radiation therapy · Tomotherapy · Proton therapy · Brachytherapy · Boron Neutron Capture Therapy (BNCT)
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v • d • e WikiDoc Research Resources for Boron Neutron Capture Therapy
Articles on Boron Neutron Capture Therapy	Most recent articles on Boron Neutron Capture Therapy • Most cited articles on Boron Neutron Capture Therapy • Review articles on Boron Neutron Capture Therapy • Articles on Boron Neutron Capture Therapy in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Boron Neutron Capture Therapy	Powerpoint slides on Boron Neutron Capture Therapy • Images of Boron Neutron Capture Therapy • Photos of Boron Neutron Capture Therapy • Podcasts & MP3s on Boron Neutron Capture Therapy • Videos on Boron Neutron Capture Therapy
Evidence Based Medicine Regarding Boron Neutron Capture Therapy	Cochrane Collaboration on Boron Neutron Capture Therapy • Bandolier on Boron Neutron Capture Therapy • TRIP on Boron Neutron Capture Therapy
Cost Effectiveness of Boron Neutron Capture Therapy	Cost Effectiveness of Boron Neutron Capture Therapy
Clinical Trials Involving Boron Neutron Capture Therapy	Ongoing Trials on Boron Neutron Capture Therapy at Clinical Trials.gov • Trial results on Boron Neutron Capture Therapy • Clinical Trials on Boron Neutron Capture Therapy at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Boron Neutron Capture Therapy	US National Guidelines Clearinghouse on Boron Neutron Capture Therapy • NICE Guidance on Boron Neutron Capture Therapy • NHS PRODIGY Guidance • FDA on Boron Neutron Capture Therapy • CDC on Boron Neutron Capture Therapy
Textbook Information on Boron Neutron Capture Therapy	Books and Textbook Information on Boron Neutron Capture Therapy
Pharmacology Resources on Boron Neutron Capture Therapy	Dosing of Boron Neutron Capture Therapy • Drug interactions with Boron Neutron Capture Therapy • Side effects of Boron Neutron Capture Therapy • Allergic reactions to Boron Neutron Capture Therapy • Overdose information on Boron Neutron Capture Therapy • Carcinogenicity information on Boron Neutron Capture Therapy • Boron Neutron Capture Therapy in pregnancy • Pharmacokinetics of Boron Neutron Capture Therapy •
Genetics, Pharmacogenomics, and Proteinomics of Boron Neutron Capture Therapy	Genetics of Boron Neutron Capture Therapy • Pharmacogenomics of Boron Neutron Capture Therapy • Proteomics of Boron Neutron Capture Therapy
Newstories on Boron Neutron Capture Therapy	Boron Neutron Capture Therapy in the news • Be alerted to news on Boron Neutron Capture Therapy • News trends on Boron Neutron Capture Therapy
Commentary on Boron Neutron Capture Therapy	Blogs on Boron Neutron Capture Therapy
Patient Resources on Boron Neutron Capture Therapy	Patient resources on Boron Neutron Capture Therapy • Discussion groups on Boron Neutron Capture Therapy • Patient Handouts on Boron Neutron Capture Therapy • Directions to Hospitals Treating Boron Neutron Capture Therapy • Risk calculators and risk factors for Boron Neutron Capture Therapy
Healthcare Provider Resources on Boron Neutron Capture Therapy	Symptoms of Boron Neutron Capture Therapy • Causes & Risk Factors for Boron Neutron Capture Therapy • Diagnostic studies for Boron Neutron Capture Therapy • Treatment of Boron Neutron Capture Therapy
Continuing Medical Education (CME) Programs on Boron Neutron Capture Therapy	CME Programs on Boron Neutron Capture Therapy
International Resources on Boron Neutron Capture Therapy	Boron Neutron Capture Therapy en Espanol • Boron Neutron Capture Therapy en Francais
Business Resources on Boron Neutron Capture Therapy	Boron Neutron Capture Therapy in the Marketplace • Patents on Boron Neutron Capture Therapy
Informatics Resources on Boron Neutron Capture Therapy	List of terms related to Boron Neutron Capture Therapy

de:BNCT

ja:中性子捕捉療法fi:BNCT

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