Basal-like carcinoma
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Overview
The basal-like breast carcinoma is a newly proposed subtype of breast cancer defined by its gene expression and protein expression profile [1]. In the current WHO breast tumor classification, these tumors are classified as ductal carcinoma. They are high grade, "triple-negative" tumors, i.e. they express no estrogen receptor, progesterone receptor nor Her2/neu proteins.
Basal-like carcinomas tend to be more aggressive, with a poor prognosis. In the U.S., they are more frequent among black women, which may explain the higher mortality rate in this group.
References
- ↑ Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma, Modern Pathology 19:264-271 (2006), via www.nature.com
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
