Autosplenectomy

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Autosplenectomy

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An autosplenectomy (from 'auto-' self, '-splen-' spleen, '-ectomy' removal) occurs when a disease damages the spleen to such an extent that it is non-functioning and so equivalent to the spleen having been surgically removed (splenectomy) .

Causes

This may occur in sickle-cell disease and spherocytosis when abnormal red blood cells repeatedly block off small blood vessels, causing infarction of parts of the spleen.

Consequences

Main article: Asplenia

Absence of effective splenic function (asplenia) is associated with increased risks of overwhelming post splenectomy infection. Protocols involving vaccination and prophylactic antibiotics can reduce these risks.

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

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