Auer rod
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-525-6884
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Auer rods can be seen in the leukemic blasts of Acute Myeloid Leukemia. Auer rods are clumps of azurophilic granular material that form elongated needles seen in the cytoplasm of leukemic blasts. They are composed of fused lysosomes and contain peroxidase, lysosomal enzymes, and large crystalline inclusions.
Diagnosis
Auer rods are classically seen in myeloid blasts of M1, M2, M3, and M4 acute leukemias.
They are also used to distinguish the pre-leukemia Myelodysplastic Syndromes: Refractory Anemia with Excess Blasts 2 (which has Auer rods) from RAEB 1 (which does not).
Pathology
 Bone marrow aspirate showing acute myeloid leukemia with Auer rods in several blasts |
 AML - Auer Rods, DIC |
 AML with Auer Rods |
Eponym
These cytoplasmic inclusions were named by John Auer, an American physiologist (1875-1948).[1]
Reference
External links
- Overview at University of Virginia
- Image at NIH/MedlinePlus
- Slides at wadsworth.org
- Image at University of Utah
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
