Anemia pathophysiology

Jump to: navigation, search

Anemia main page

Overview

Classification

Differential Diagnosis

Medical Therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Please help WikiDoc by adding more content here. It's easy! Click here to learn about editing.

Overview

Erythropoietin produced in the kidneys are the major stimulant of red blood cell (RBC) production as a response to anemia. Erythropoietin is stimulated by tissue hypoxia, that in turn stimulates erythroid progenitor cells to proliferate. The EPO levels follow a reverse relationship with the hemoglobin levels. Thus, in normal hosts, low levels of hemoglobin are associated with high levels of EPO. However, in patients with chronic kidney disease and anemia of chronic diseases the response may not be as strong as seen in patients without these comorbidities.

Pathophysiology

References



Linked-in.jpg