Amacrine cell
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| Amacrine cell | |
|---|---|
| | |
| Location | INL of the retina |
| Function | inhibitory or neuromodulatory interneurons |
| Neurotransmitter | GABA, glycine, DA, or 5-HT |
| Morphology | Varies |
| Presynaptic connections | Bipolar cells |
| Postsynaptic connections | Bipolar cells and Ganglion cells |
Amacrine cells are interneurons in the retina which deliver 70% of the ganglion cells input, and also regulates the output of the cone bipolar cells which deliver the other 30%.
Contents |
Overview
Amacrine cells operate at the inner plexiform layer (IPL), the second synaptic retinal layer where bipolar cells and ganglion cells synapse. There are about 40 different types of amacrine cells, most lacking axons. Like horizontal cells, amacrine cells work laterally affecting the output from bipolar cells, however, their tasks are often more specialized. Each type of amacrine cell connects with a particular type of bipolar cell, and generally has a particular type of neurotransmitter. One such population, AII, 'piggybacks' rod bipolar cells onto the cone bipolar circuitry. It connects rod bipolar cell output with cone bipolar cell input, and from there the signal can travel to the respective ganglion cells.
They are classified by the width of their field of connection, which layer(s) of the stratum in the IPL they are in, and by neurotransmitter type. Most are inhibitory using either GABA or glycine as neurotransmitters.
Functionality
Functionally, they are responsible for complex processing of the retinal image, specifically adjusting image brightness and, by integrating sequential activation of neurons, detecting motion.
See also
References
- Nicholls, John G.; A. Robert Martin, Bruce G. Wallace, Paul A. Fuchs (2001). From Neuron to Brain. Boston, Massachusetts: Sinauer Associates, Inc. ISBN 0-87893-439-1.
- Masland RH (2001). "The fundamental plan of the retina". Nat. Neurosci. 4 (9): 877-86. doi:10.1038/nn0901-877. PMID 11528418.
External links
de:AmakrinzelleAcknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
