Alpha-ribazole phosphatase

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In enzymology, an alpha-ribazole phosphatase (EC 3.1.3.73) is an enzyme that catalyzes the chemical reaction

alpha-ribazole 5'-phosphate + H2O alpha-ribazole + phosphate

Thus, the two substrates of this enzyme are alpha-ribazole 5'-phosphate and H2O, whereas its two products are alpha-ribazole and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is alpha-ribazole-5'-phosphate phosphohydrolase. This enzyme is also called CobC. This enzyme participates in porphyrin and chlorophyll metabolism.

Structural studies

As of late 2007, 16 structures have been solved for this class of enzymes, with PDB accession codes 2ENU, 2ENW, 2EOA, 2OWE, 2P2Y, 2P2Z, 2P30, 2P6M, 2P6O, 2P75, 2P77, 2P78, 2P79, 2P9Y, 2P9Z, and 2PA0.

References

  • IUBMB entry for 3.1.3.73
  • BRENDA references for 3.1.3.73 (Recommended.)
  • PubMed references for 3.1.3.73
  • PubMed Central references for 3.1.3.73
  • Google Scholar references for 3.1.3.73
  • O'Toole GA, Trzebiatowski JR, Escalante-Semerena JC (1994). "The cobC gene of Salmonella typhimurium codes for a novel phosphatase involved in the assembly of the nucleotide loop of cobalamin". J. Biol. Chem. 269: 26503&ndash, 11. PMID 7929373.
  • Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (2002). "The biosynthesis of adenosylcobalamin (vitamin B12)". Nat. Prod. Rep. 19: 390&ndash, 412. PMID 12195810.

External links

The CAS registry number for this enzyme class is 251991-06-7.

Gene Ontology (GO) codes


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