Alpha-amino-acid esterase

Jump to: navigation, search

In enzymology, an alpha-amino-acid esterase (EC 3.1.1.43) is an enzyme that catalyzes the chemical reaction

an alpha-amino acid ester + H2O an alpha-amino acid + an alcohol

Thus, the two substrates of this enzyme are alpha-amino acid ester and H2O, whereas its two products are alpha-amino acid and alcohol.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is alpha-amino-acid-ester aminoacylhydrolase. This enzyme is also called alpha-amino acid ester hydrolase.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1MPX, 1NX9, 1RYY, 2B4K, and 2B9V.

References

  • IUBMB entry for 3.1.1.43
  • BRENDA references for 3.1.1.43 (Recommended.)
  • PubMed references for 3.1.1.43
  • PubMed Central references for 3.1.1.43
  • Google Scholar references for 3.1.1.43
  • Kato K, Kawahara K, Takahashi T and Kakinuma A (1980). "Purification of an alpha-amino acid ester hydrolase from Xanthomonas citri". Agric. Biol. Chem. 44: 1069&ndash, 1074.
  • Kato K, Kawahara K, Takahashi T and Kakinuma A (1980). "Substrate specificity of an alpha-amino acid ester hydrolase from Xanthomonas citri". Agric. Biol. Chem. 44: 1075&ndash, 1081.
  • Takahashi T, Yamazaki Y, Kato K (1974). "Substrate specificity of an alpha-amino acid ester hydrolase produced by Acetobacter turbidans A.T.C.C. 9325". Biochem. J. 137: 497&ndash, 503. PMID 4424889.

External links

The CAS registry number for this enzyme class is 74506-40-4.

Gene Ontology (GO) codes


Linked-in.jpg