Alkylglycerophosphoethanolamine phosphodiesterase

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In enzymology, an alkylglycerophosphoethanolamine phosphodiesterase (EC is an enzyme that catalyzes the chemical reaction

1-alkyl-sn-glycero-3-phosphoethanolamine + H2O 1-alkyl-sn-glycerol 3-phosphate + ethanolamine

Thus, the two substrates of this enzyme are 1-alkyl-sn-glycero-3-phosphoethanolamine and H2O, whereas its two products are 1-alkyl-sn-glycerol 3-phosphate and ethanolamine.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is 1-alkyl-sn-glycero-3-phosphoethanolamine ethanolaminehydrolase. This enzyme is also called lysophospholipase D. This enzyme participates in ether lipid metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1FJ2.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Wykle RL, Schremmer JM (1974). "A lysophospholipase D pathway in the metabolism of ether-linked lipids in brain microsomes". J. Biol. Chem. 249: 1742&ndash, 6. PMID 4855486.

External links

The CAS registry number for this enzyme class is 62213-15-4.

Gene Ontology (GO) codes