Alclometasone

Jump to: navigation, search
220px
Alclometasone
Systematic (IUPAC) name
[7-chloro-11-hydroxy- 10,13,16-trimethyl-3-oxo-17- (2-propanoyloxyacetyl)- 7,8,9,11,12, 14,15,16- octahydro-6H-cyclopenta[a]phenanthren-17-yl] propanoate
Identifiers
CAS number 66734-13-2
ATC code D07AB10 S01BA10
PubChem 636374
DrugBank APRD00783
Chemical data
Formula C28H37ClO7 
Mol. mass 521.042 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes topical

Contents

Description

Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.
Alclometasone Dipropionate marketed as medication Aclovate by GlaxoSmithKline.

Pharmacology

Alclometasone inhibits phospholipase A2 by inducing production of lipocortins; inhibits synthesis of arachidonic acid, prostaglandins and leukotrienes acid, reduce release of cytokines from lymphocytes and others mediators of inflammation (incl. histamine).

Indications

Alclometasone cream and onintment are indicated for the relief of corticosteroid-responsive dermatoses, including:

  • atopic dermatitis
  • eczema
  • psoriasis
  • allergic dermatitis
  • contact dermatitis
  • actinic dermatitis
  • kiss-type allergy
  • skin itch
    Alclometasone may be used on sensetive skin sites (face, skinfolds); in pediatric patients 1 year or older and in geriatric patients.

    Contraindications

  • hypersensitivity to alclometasone or any of ingredients in pharmaceutical forms
  • cutaneous tuberculosis
  • chicken pox
  • perioral dermatitis
  • acne
  • rosacea
  • open wounds
  • trophic ulcers
  • viral infection of skin
  • skin manifestations of syphilis

    Side effects

    Alclometasone Adverse reactions/Side effects (sometimes, less than 1-2% cases) include:

  • burning
  • itching
  • erythema
  • skin reddening
  • xerodermia
  • skin irritation
  • acne
  • hypopigmentation
  • prickly heat
  • folliculitis
  • white atrophy
  • hypertrichosis
  • reinfection of skin

    How supplied

    Alclometasone as Aclovate® is supplied in:

  • Cream; Topical; 0.05%
  • Ointment; Topical; 0.05%

    External links

    v • d • e
    Corticosteroids - glucocorticoid/receptor and mineralocorticoid/receptor
    (A07EA, C05AA, D07, D10AA, H02, R01AD, R03BA, S01BA, S02B, and S03B)
    EndogenousAldosterone, Cortisone, Hydrocortisone/cortisol, Desoxycortone
    OthersAlclometasone, Amcinonide, Beclometasone, Betamethasone, Budesonide, Ciclesonide, Clobetasol, Clobetasone, Clocortolone, Cloprednol, Cortivazol, Deflazacort, Deoxycorticosterone, Desonide, Desoximetasone, Dexamethasone, Diflorasone, Diflucortolone, Difluprednate, Fluclorolone, Fludrocortisone, Fludroxycortide, Flumetasone, Flunisolide, Fluocinolone acetonide, Fluocinonide, Fluocortin, Fluocortolone, Fluorometholone, Fluperolone, Fluprednidene, Fluticasone, Formocortal, Halcinonide, Halometasone, Hydrocortisone aceponate, Hydrocortisone buteprate, Hydrocortisone butyrate, Loteprednol, Medrysone, Meprednisone, Methylprednisolone,Methylprednisolone aceponate, Mometasone furoate, Paramethasone, Prednicarbate, Prednisone, Prednisolone, Prednylidene, Rimexolone, Tixocortol, Triamcinolone, Ulobetasol
    • Retrieved from "http://www.wikidoc.org/index.php?title=Alclometasone&oldid=604221"
    Navigation WikiDoc | WikiPatient | Popular pages | Recently Edited Pages | Recently Added Pictures

    Table of Contents In Alphabetical Order | By Individual Diseases | Signs and Symptoms | Physical Examination | Lab Tests | Drugs

    Editor Tools Become an Editor | Editors Help Menu | Create a Page | Edit a Page | Upload a Picture or File | Printable version | Permanent link | Maintain Pages | What Pages Link Here
    There is no pharmaceutical or device industry support for this site and we need your viewer supported Donations | Editorial Board | Governance | Licensing | Disclaimers | Avoid Plagiarism | Policies
    Linked-in.jpg
    Personal tools
    Namespaces

    Variants
    Actions
    Navigation
    Toolbox
    In other languages