Alclometasone
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| Image:Alclometasone.png | |
| Alclometasone
| |
| Systematic (IUPAC) name | |
| [7-chloro-11-hydroxy- 10,13,16-trimethyl-3-oxo-17- (2-propanoyloxyacetyl)- 7,8,9,11,12, 14,15,16- octahydro-6H-cyclopenta[a]phenanthren-17-yl] propanoate | |
| Identifiers | |
| CAS number | |
| ATC code | D07 S01BA10 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C28H37ClO7 |
| Mol. mass | 521.042 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | topical |
Contents |
Description
Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.
Alclometasone Dipropionate marketed as medication Aclovate by GlaxoSmithKline.
Pharmacology
Alclometasone inhibits phospholipase A2 by inducing production of lipocortins;
inhibits synthesis of arachidonic acid, prostaglandins and leukotrienes acid,
reduce release of cytokines from lymphocytes and others mediators of inflammation (incl. histamine).
Indications
Alclometasone cream and onintment are indicated for the relief of corticosteroid-responsive dermatoses, including:
Alclometasone may be used on sensetive skin sites (face, skinfolds); in pediatric patients 1 year or older and in geriatric patients.
Contraindications
Side effects
Alclometasone Adverse reactions/Side effects (sometimes, less than 1-2% cases) include:
How supplied
Alclometasone as Aclovate® is supplied in:
External links
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
