|Systematic (IUPAC) name|
|[7-chloro-11-hydroxy- 10,13,16-trimethyl-3-oxo-17- (2-propanoyloxyacetyl)- 7,8,9,11,12, 14,15,16- octahydro-6H-cyclopenta[a]phenanthren-17-yl] propanoate|
|ATC code||D07 S01BA10|
|Mol. mass||521.042 g/mol|
Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.
Alclometasone Dipropionate marketed as medication Aclovate by GlaxoSmithKline.
Alclometasone inhibits phospholipase A2 by inducing production of lipocortins;
inhibits synthesis of arachidonic acid, prostaglandins and leukotrienes acid,
reduce release of cytokines from lymphocytes and others mediators of inflammation (incl. histamine).
Alclometasone cream and onintment are indicated for the relief of corticosteroid-responsive dermatoses, including:
Alclometasone may be used on sensetive skin sites (face, skinfolds); in pediatric patients 1 year or older and in geriatric patients.
Alclometasone Adverse reactions/Side effects (sometimes, less than 1-2% cases) include:
Alclometasone as Aclovate® is supplied in:
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