Alatrofloxacin

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Alatrofloxacin
Systematic (IUPAC) name
7-[(1R,5S)-6-{[(2S)-1-{[(2S)-2-aminopropanoyl]amino}- 1-oxopropan-2-yl]amino}-3-azabicyclo[3.1.0]hexan-3-yl]- 1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine- 3-carboxylic acid
Identifiers
CAS number	157182-32-6 157605-25-9 (mesylate)
ATC code	?
PubChem	5489474
Chemical data
Formula	C26H25F3N6O5
Mol. mass	558.509 g/mol
Pharmacokinetic data
Bioavailability	N/A
Protein binding	76% (trovafloxacin)
Metabolism	Quickly hydrolyzed to trovafloxacin
Half life	9 to 12 hours (trovafloxacin)
Excretion	Fecal and renal (trovafloxacin)
Therapeutic considerations
Pregnancy cat.	C(US)
Legal status	Withdrawn
Routes	Intravenous

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Evidence Based Medicine
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Clinical Trials
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Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Alatrofloxacin NICE Guidance on Alatrofloxacin NHS PRODIGY Guidance FDA on Alatrofloxacin CDC on Alatrofloxacin
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Experimental / Informatics
List of terms related to Alatrofloxacin

Alatrofloxacin (Trovan IV) is a fluoroquinolone antibiotic developed by Pfizer, delivered as a mesylate salt. It is the parental prodrug of trovafloxacin (Trovan) meant for intravenous administration. Trovafloxacin is a broad-spectrum antibiotic introduced in 1998 which encountered criticism for its Nigerian trials and adverse clinical reactions.

Trovafloxacin and alatrofloxacin were both withdrawn from the U.S. market in 2001.