Aggressive NK-cell leukemia other diagnostic studies

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Aggressive NK-cell leukemia Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Molecular Findings

Immunophenotype

The immunophenotype of this disease is the same as extranodal NK/T-cell lymphoma, nasal type and is shown in the table below. CD11b and CD16 show variable expression.

Status Antigens
Positive CD2, CD3ε, CD56, perforin, granzyme B, TIA-1
Negative CD57

Genetic Findings

Due to the myeloid lineage, clonal rearrangements of lymphoid (T cell receptor; B cell receptor) genes are not seen. The genome of the Epstein Barr virus (EBV) is detected in many cases, along with a variety of chromosomal abnormalities.[2] Wong KF, Zhang YM, Chan JK. "Cytogenetic abnormalities in natural killer cell lymphoma/leukaemia--is there a consistent pattern?" Leuk Lymphoma. 1999 Jul;34(3-4):241-50.

References


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