Adenosine thiamine triphosphate

Adenosine thiamine triphosphate
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Identifiers
CAS number
MeSH	adenosine+thiamine+triphosphate
Properties
Molecular formula	C22H28N9O13P3S2-
Molar mass	751.498 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Adenosine thiamine triphosphate (AThTP), or thiaminylated adenosine triphosphate (ATP) is a natural thiamine adenine nucleotide. It was discovered in Escherichia coli where it may account for up to 15 - 20 % of total thiamine under carbon starvation. AThTP exists also, though at much lower levels, in eukaryotic organisms such as yeast, roots of higher plants and animal tissues. In E. coli AThTP is synthesized from thiamine diphosphate (ThDP) according the reaction ThDP + ATP (ADP) ↔ AThDP + PP_i (P_i) by an thiamine diphosphate adenylyl transferase.

References

• Bettendorff L, Wirtzfeld B, Makarchikov AF, et al (2007). "Discovery of a natural thiamine adenine nucleotide". Nat. Chem. Biol. 3 (4): 211-2. doi:10.1038/nchembio867. PMID 17334376.

• A first for vitamins. Nature 446 (2007) 112[1]

• Jordan F (2007). "Adenosine triphosphate and thiamine cross paths". Nat. Chem. Biol. 3 (4): 202-3. doi:10.1038/nchembio0407-202. PMID 17372602.

• Makarchikov AF, Brans A and Bettendorff L (2007). "Thiamine diphosphate adenylyl transferase from E. coli: functional characterization of the enzyme synthesizing adenosine thiamine triphosphate". BMC Biochem. 8. doi:10.1186/1471-2091-8-17. PMID 17705845.