Adducted thumb syndrome

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Adducted thumb syndrome Classification and external resources
OMIM	201550

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Overview

Adducted thumb syndrome recessive form is a rare disease also known as Christian syndrome or Craniostenosis arthrogryposis cleft palate. The disease was first documented in 1971 by Dr. Joe Christian and three associates after examining three Amish siblings^[1]. All six parents shared a common ancestral couple, making this a possible issue with consanguinity. An additional case was described in 1975^[2]. Inheritance is believed to be autosomal recessive.

This syndrome is associated with microcephaly, arthrogryposis, and cleft palate and various craniofacial, respiratory, neurological, and limb abnormalities, including bone and joint defects of the upper limbs, adducted thumbs, camptodactly, and talipes equinovarus or calcaneovalgus. Patients with the disease are considered mentally retarded, and most die in childhood. Patients often suffer from respiratory difficulties, such as pneumonia, and from seizures due to dysmyelination in the white matter.^[3] It has been hypothesized that the Moro reflex (startle reflex in infants) may be a tool in detecting the congenital clapsed thumb early in infancy^[4] The thumb will normally extend as a result of this reflex.

References

External links

• Whonamedit.com entry on Christian syndrome

v • d • e Phakomatoses and other congenital malformations not elsewhere classified (Q85-Q89, 759)
Phakomatoses	Abdallat Davis Farrage syndrome - Ataxia telangiectasia - Incontinentia pigmenti - Neurofibromatosis (type I, type II) - Peutz-Jeghers syndrome - Sturge-Weber syndrome - Tuberous sclerosis - Von Hippel-Lindau disease
Due to known exogenous causes	Fetal alcohol syndrome - Phocomelia (via Thalidomide)
Affecting multiple systems	facial (Mobius syndrome, Goldenhar syndrome, Cyclopia, Apert syndrome) short stature (Aarskog-Scott syndrome, Cockayne syndrome, Cornelia de Lange Syndrome, Dubowitz syndrome, Noonan syndrome, Robinow syndrome, Silver-Russell dwarfism, Seckel syndrome, Smith-Lemli-Opitz syndrome) limbs (Adducted thumb syndrome, Holt-Oram syndrome, Klippel-Trenaunay-Weber syndrome, Nail-patella syndrome, Rubinstein-Taybi syndrome, Sirenomelia, VACTERL association) overgrowth (Beckwith-Wiedemann syndrome, Sotos syndrome, Weaver syndrome) combined/other Ablepharon macrostomia syndrome - Alport syndrome - Bardet-Biedl syndrome - Branchio-oto-renal syndrome - Donohue syndrome - Fraser syndrome - Keutel syndrome - Marfan syndrome - Timothy syndrome - Urban-Rogers-Meyer syndrome - Vici syndrome - Yunis-Varon syndrome - Zellweger syndrome - Zimmerman-Laband syndrome - Zori Stalker Williams syndrome
Other	spleen: Asplenia - Splenomegaly endocrine glands: Persistent thyroglossal duct - Thyroglossal cyst Conjoined twins - Cowden syndrome - Hamartoma - Impossible syndrome - Situs inversus

v • d • e WikiDoc Research Resources for Adducted thumb syndrome
Articles on Adducted thumb syndrome	Most recent articles on Adducted thumb syndrome • Most cited articles on Adducted thumb syndrome • Review articles on Adducted thumb syndrome • Articles on Adducted thumb syndrome in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Adducted thumb syndrome	Powerpoint slides on Adducted thumb syndrome • Images of Adducted thumb syndrome • Photos of Adducted thumb syndrome • Podcasts & MP3s on Adducted thumb syndrome • Videos on Adducted thumb syndrome
Evidence Based Medicine Regarding Adducted thumb syndrome	Cochrane Collaboration on Adducted thumb syndrome • Bandolier on Adducted thumb syndrome • TRIP on Adducted thumb syndrome
Cost Effectiveness of Adducted thumb syndrome	Cost Effectiveness of Adducted thumb syndrome
Clinical Trials Involving Adducted thumb syndrome	Ongoing Trials on Adducted thumb syndrome at Clinical Trials.gov • Trial results on Adducted thumb syndrome • Clinical Trials on Adducted thumb syndrome at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Adducted thumb syndrome	US National Guidelines Clearinghouse on Adducted thumb syndrome • NICE Guidance on Adducted thumb syndrome • NHS PRODIGY Guidance • FDA on Adducted thumb syndrome • CDC on Adducted thumb syndrome
Textbook Information on Adducted thumb syndrome	Books and Textbook Information on Adducted thumb syndrome
Pharmacology Resources on Adducted thumb syndrome	Dosing of Adducted thumb syndrome • Drug interactions with Adducted thumb syndrome • Side effects of Adducted thumb syndrome • Allergic reactions to Adducted thumb syndrome • Overdose information on Adducted thumb syndrome • Carcinogenicity information on Adducted thumb syndrome • Adducted thumb syndrome in pregnancy • Pharmacokinetics of Adducted thumb syndrome •
Genetics, Pharmacogenomics, and Proteinomics of Adducted thumb syndrome	Genetics of Adducted thumb syndrome • Pharmacogenomics of Adducted thumb syndrome • Proteomics of Adducted thumb syndrome
Newstories on Adducted thumb syndrome	Adducted thumb syndrome in the news • Be alerted to news on Adducted thumb syndrome • News trends on Adducted thumb syndrome
Commentary on Adducted thumb syndrome	Blogs on Adducted thumb syndrome
Patient Resources on Adducted thumb syndrome	Patient resources on Adducted thumb syndrome • Discussion groups on Adducted thumb syndrome • Patient Handouts on Adducted thumb syndrome • Directions to Hospitals Treating Adducted thumb syndrome • Risk calculators and risk factors for Adducted thumb syndrome
Healthcare Provider Resources on Adducted thumb syndrome	Symptoms of Adducted thumb syndrome • Causes & Risk Factors for Adducted thumb syndrome • Diagnostic studies for Adducted thumb syndrome • Treatment of Adducted thumb syndrome
Continuing Medical Education (CME) Programs on Adducted thumb syndrome	CME Programs on Adducted thumb syndrome
International Resources on Adducted thumb syndrome	Adducted thumb syndrome en Espanol • Adducted thumb syndrome en Francais
Business Resources on Adducted thumb syndrome	Adducted thumb syndrome in the Marketplace • Patents on Adducted thumb syndrome
Informatics Resources on Adducted thumb syndrome	List of terms related to Adducted thumb syndrome