Abelson leukemia virus protein
| v-abl Abelson murine leukemia viral oncogene homolog 1
| |
| Identifiers | |
| Symbol | ABL1 |
| Alt. Symbols | ABL |
| Entrez | 25 |
| HUGO | 76 |
| OMIM | 189980 |
| RefSeq | NM_007313 |
| UniProt | P00519 |
| Other data | |
| Locus | Chr. 9 q34.1 |
Abl (Abelson leukemia virus protein, chromosome 9q34) is an important tyrosine kinase. This gene is fused with the bcr gene in a Philadelphia chromosome, the characteristic abnormality in chronic myelogenous leukemia (CML) and rarely in some other leukemia forms. The bcr-abl transcript is also a tyrosine kinase, which activates mediators of the cell cycle regulation system, leading to a clonal myeloproliferative disorder. The bcr-abl protein can be inhibited with the agent imatinib mesylate, which occupies the TK domain and inhibits bcr-abls influence on the cell cycle.
External links
Kinases: tyrosine kinases (EC 2.7.10) | |
|---|---|
| 2.7.10.1 | Receptor tyrosine kinase |
| 2.7.10.2 | Abelson leukemia virus protein - c-Kit - C-MET - Flt3 - Janus kinase (Janus kinase 1, Janus kinase 2, Janus kinase 3, Tyrosine kinase 2) - Src (Lck) - Syk - ZAP-70 |
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