AKAP10

A kinase (PRKA) anchor protein 10
Identifiers
Symbol(s)	AKAP10; D-AKAP2; MGC9414; PRKA10
External IDs	OMIM: 604694 MGI: 1890218 Homologene: 32452
Gene ontology Molecular Function: • signal transducer activity • protein binding • kinase activity Cellular Component: • mitochondrion Biological Process: • signal transduction • protein localization
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	11216	56697
Ensembl	ENSG00000108599	ENSMUSG00000047804
Uniprot	O43572	Q3TR91
Refseq	NM_007202 (mRNA) NP_009133 (protein)	NM_019921 (mRNA) NP_064305 (protein)
Location	Chr 17: 19.75 - 19.82 Mb	Chr 11: 61.69 - 61.75 Mb
Pubmed search	[1]	[2]

A kinase (PRKA) anchor protein 10, also known as AKAP10, is a human gene.

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein interacts with both the type I and type II regulatory subunits of PKA; therefore, it is a dual-specific AKAP. This protein is highly enriched in mitochondria. It contains RGS (regulator of G protein signalling) domains, in addition to a PKA-RII subunit-binding domain. The mitochondrial localization and the presence of RGS domains may have important implications for the function of this protein in PKA and G protein signal transduction.

Further reading

• Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases.". Recent Prog. Horm. Res. 52: 409-29; discussion 429-30. PMID 9238861.
• Michel JJ, Scott JD (2002). "AKAP mediated signal transduction.". Annu. Rev. Pharmacol. Toxicol. 42: 235-57. doi:10.1146/annurev.pharmtox.42.083101.135801. PMID 11807172.
• Epplen C, Epplen JT (1994). "Expression of (cac)n/(gtg)n simple repetitive sequences in mRNA of human lymphocytes.". Hum. Genet. 93 (1): 35-41. PMID 7505766.
• Huang LJ, Durick K, Weiner JA, et al. (1997). "D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain.". Proc. Natl. Acad. Sci. U.S.A. 94 (21): 11184-9. PMID 9326583.
• Wang L, Sunahara RK, Krumins A, et al. (2001). "Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein.". Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3220-5. doi:10.1073/pnas.051633398. PMID 11248059.
• Hamuro Y, Burns L, Canaves J, et al. (2002). "Domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS).". J. Mol. Biol. 321 (4): 703-14. PMID 12206784.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Kammerer S, Burns-Hamuro LL, Ma Y, et al. (2003). "Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism.". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4066-71. doi:10.1073/pnas.2628028100. PMID 12646697.
• Gisler SM, Pribanic S, Bacic D, et al. (2004). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells.". Kidney Int. 64 (5): 1733-45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.
• Burns-Hamuro LL, Barraclough DM, Taylor SS (2005). "Identification and functional analysis of dual-specific A kinase-anchoring protein-2.". Meth. Enzymol. 390: 354-74. doi:10.1016/S0076-6879(04)90022-5. PMID 15488188.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
• Tingley WG, Pawlikowska L, Zaroff JG, et al. (2007). "Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation.". Proc. Natl. Acad. Sci. U.S.A. 104 (20): 8461-6. doi:10.1073/pnas.0610393104. PMID 17485678.