ACTL6A

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Actin-like 6A
Identifiers
Symbol(s) ACTL6A; ACTL6; BAF53A; MGC5382
External IDs OMIM: 604958 MGI: 1861453 Homologene: 55811
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 86 56456
Ensembl ENSG00000136518 ENSMUSG00000027671
Uniprot O96019 Q3TF62
Refseq NM_004301 (mRNA)
NP_004292 (protein) 		NM_019673 (mRNA)
NP_062647 (protein)
Location Chr 3: 180.76 - 180.79 Mb Chr 3: 32.9 - 32.92 Mb
Pubmed search [1] [2]

Actin-like 6A, also known as ACTL6A, is a human gene.[1]


This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.[1]


References

  1. ↑ 1.0 1.1 Entrez Gene: ACTL6A actin-like 6A.

Further reading

  • Schafer DA, Schroer TA (2000). "Actin-related proteins.". Annu. Rev. Cell Dev. Biol. 15: 341-63. doi:10.1146/annurev.cellbio.15.1.341. PMID 10611965.
  • Doyon Y, Côté J (2004). "The highly conserved and multifunctional NuA4 HAT complex.". Curr. Opin. Genet. Dev. 14 (2): 147-54. doi:10.1016/j.gde.2004.02.009. PMID 15196461.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
  • Cho H, Orphanides G, Sun X, et al. (1998). "A human RNA polymerase II complex containing factors that modify chromatin structure.". Mol. Cell. Biol. 18 (9): 5355-63. PMID 9710619.
  • Zhao K, Wang W, Rando OJ, et al. (1998). "Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling.". Cell 95 (5): 625-36. PMID 9845365.
  • Phelan ML, Sif S, Narlikar GJ, Kingston RE (1999). "Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits.". Mol. Cell 3 (2): 247-53. PMID 10078207.
  • Harata M, Mochizuki R, Mizuno S (1999). "Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues.". Biosci. Biotechnol. Biochem. 63 (5): 917-23. PMID 10380635.
  • Ikura T, Ogryzko VV, Grigoriev M, et al. (2000). "Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis.". Cell 102 (4): 463-73. PMID 10966108.
  • Xue Y, Canman JC, Lee CS, et al. (2001). "The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes.". Proc. Natl. Acad. Sci. U.S.A. 97 (24): 13015-20. doi:10.1073/pnas.240208597. PMID 11078522.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
  • Sung YH, Choi EY, Kwon H (2001). "Identification of a nuclear protein ArpN as a component of human SWI/SNF complex and its selective association with a subset of active genes.". Mol. Cells 11 (1): 75-81. PMID 11266125.
  • Lai CH, Chiu JY, Lin W (2001). "Identification of the human crooked neck gene by comparative gene identification.". Biochim. Biophys. Acta 1517 (3): 449-54. PMID 11342225.
  • Fuchs M, Gerber J, Drapkin R, et al. (2001). "The p400 complex is an essential E1A transformation target.". Cell 106 (3): 297-307. PMID 11509179.
  • Kato H, Tjernberg A, Zhang W, et al. (2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones.". J. Biol. Chem. 277 (7): 5498-505. doi:10.1074/jbc.M108702200. PMID 11734557.
  • Park J, Wood MA, Cole MD (2002). "BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation.". Mol. Cell. Biol. 22 (5): 1307-16. PMID 11839798.
  • Ohfuchi E, Nishimori K, Harata M (2003). "Alternative splicing products of the gene for a human nuclear actin-related protein, hArpNbeta/Baf53, that encode a protein isoform, hArpNbetaS, in the cytoplasm.". Biosci. Biotechnol. Biochem. 66 (8): 1740-3. PMID 12353638.
  • Kuroda Y, Oma Y, Nishimori K, et al. (2003). "Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex.". Biochem. Biophys. Res. Commun. 299 (2): 328-34. PMID 12437990.
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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

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