5-aminovalerate transaminase

In enzymology, a 5-aminovalerate transaminase (EC 2.6.1.48) is an enzyme that catalyzes the chemical reaction

5-aminopentanoate + 2-oxoglutarate <math>\rightleftharpoons</math> 5-oxopentanoate + L-glutamate

Thus, the two substrates of this enzyme are 5-aminopentanoate and 2-oxoglutarate, whereas its two products are 5-oxopentanoate and L-glutamate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is 5-aminopentanoate:2-oxoglutarate aminotransferase. Other names in common use include 5-aminovalerate aminotransferase, delta-aminovalerate aminotransferase, and delta-aminovalerate transaminase. This enzyme participates in lysine degradation. It employs one cofactor, pyridoxal phosphate.

References

• IUBMB entry for 2.6.1.48
• BRENDA references for 2.6.1.48 (Recommended.)
• PubMed references for 2.6.1.48
• PubMed Central references for 2.6.1.48
• Google Scholar references for 2.6.1.48
• Ichihara A, Ichihara EA and Suda M (Tokyo). "Metabolism of L-lysine by bacterial enzymes. IV. delta-Aminovaleric acid-glutamic acid transaminase". J. Biochem.: 412–420.

External links

The CAS registry number for this enzyme class is 37277-97-7.

• IUBMB entry for 2.6.1.48

• KEGG entry for 2.6.1.48

• BRENDA entry for 2.6.1.48

• NiceZyme view of 2.6.1.48

• EC2PDB: PDB structures for 2.6.1.48

• PRIAM entry for 2.6.1.48

• PUMA2 entry for 2.6.1.48

• IntEnz: Integrated Enzyme entry for 2.6.1.48

• MetaCyc entry for 2.6.1.48

• Atomic-resolution structures of enzymes belonging to this class

Gene Ontology (GO) codes

• EGO entry for GO code 0047589: 5-aminovalerate transaminase

• AMIGO entry for GO code 0047589: 5-aminovalerate transaminase