4-hydroxyglutamate transaminase

In enzymology, a 4-hydroxyglutamate transaminase (EC 2.6.1.23) is an enzyme that catalyzes the chemical reaction

4-hydroxy-L-glutamate + 2-oxoglutarate <math>\rightleftharpoons</math> 4-hydroxy-2-oxoglutarate + L-glutamate

Thus, the two substrates of this enzyme are 4-hydroxy-L-glutamate and 2-oxoglutarate, whereas its two products are 4-hydroxy-2-oxoglutarate and L-glutamate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is 4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase. This enzyme is also called 4-hydroxyglutamate aminotransferase. This enzyme participates in arginine and proline metabolism.

References

IUBMB entry for 2.6.1.23
BRENDA references for 2.6.1.23 (Recommended.)
PubMed references for 2.6.1.23
PubMed Central references for 2.6.1.23
Google Scholar references for 2.6.1.23
GOLDSTONE A, ADAMS E (1962). "Metabolism of gamma-hydroxyglutamic acid. I. Conversion to alpha-hydroxy-gamma-ketoglutarate by purified glutamic-aspartic transaminase to rat liver". J. Biol. Chem. 237: 3476–85. PMID 13948827.
KURATOMI K, FUKUNAGA K, KOBAYASHI Y (1963). "THE METABOLISM OF GAMMA-HYDROXYGLUTAMATE IN RAT LIVER. II. A TRANSAMINASE CONCERNED IN GAMMA-HYDROXYGLUTAMATE METABOLISM". Biochim. Biophys. Acta. 78: 629–36. PMID 14089443.