1-acylglycerophosphocholine O-acyltransferase

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In enzymology, a 1-acylglycerophosphocholine O-acyltransferase (EC 2.3.1.23) is an enzyme that catalyzes the chemical reaction

acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine CoA + 1,2-diacyl-sn-glycero-3-phosphocholine

Thus, the two substrates of this enzyme are acyl-CoA and 1-acyl-sn-glycero-3-phosphocholine, whereas its two products are CoA and 1,2-diacyl-sn-glycero-3-phosphocholine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase. Other names in common use include lysolecithin acyltransferase, 1-acyl-sn-glycero-3-phosphocholine acyltransferase, acyl coenzyme A-monoacylphosphatidylcholine acyltransferase, acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase, lysophosphatide acyltransferase, and lysophosphatidylcholine acyltransferase. This enzyme participates in glycerophospholipid metabolism.

References

  • IUBMB entry for 2.3.1.23
  • BRENDA references for 2.3.1.23 (Recommended.)
  • PubMed references for 2.3.1.23
  • PubMed Central references for 2.3.1.23
  • Google Scholar references for 2.3.1.23
  • Bell RM, Coleman RA (1980). "Enzymes of glycerolipid synthesis in eukaryotes". Annu. Rev. Biochem. 49: 459&ndash, 87. PMID 6250446.
  • Hill EE, Lands WE (1968). "Incorporation of long-chain and polyunsaturated acids into phosphatidate and phosphatidylcholine". Biochim. Biophys. Acta. 152: 645&ndash, 8. PMID 5661029.
  • Miki Y, Hosaka K, Yamashita S, Handa H, Numa S (1977). "Acyl-acceptor specificities of 1-acylglycerolphosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase resolved from rat liver microsomes". Eur. J. Biochem. 81: 433&ndash, 41. PMID 598375.
  • van den Bosch H, van Golde LM, Eibl H, van Deenen LL (1967). "The acylation of 1-acylglycero-3-phosphorylcholines by rat-liver microsomes". Biochim. Biophys. Acta. 144: 613&ndash, 23. PMID 6078124.

External links

The CAS registry number for this enzyme class is 9027-64-9.

Gene Ontology (GO) codes


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